Relationship Of Gamma-glutamyltransferase With Pulmonary Function And Chronic Obstructive Pulmonary Disease In Male Patients

Objective:Chronic obstructive pulmonary disease(COPD) is a frequently-occurring disease,commom diseaseof serious harm to human health. According to statistics, it will become the fifth of the economic burden in the world. And it will maybe rise for the third death worldwide by 2020. Systemic inflammation and oxidative stress is the most important feature of chronic obstructive pulmonary disease. Recent studies have found an association between liver enzymes γ- glutamyltransferase(GGT) and the pathogenesis of chronic obstructive pulmonary disease.By means of discussing the relationship of serum GGT levels with pulmonary function and chronic obstructive pulmonary disease in male patients that can provide new evidence for the early discovery, prevention and treatment of chronic obstructive pulmonary disease.Methods:127 male patients hospitalized and clinic in Respiratory Department of the Second Hospital of Shan Xi Medical University from 2012 June to 2014 February were collected.All patients had been taken pulmonary function tests. Meanwhile, all patients were excluded liver disease and gallbladder disease. A total of 127 male patients were divided into four groups quartile, based on serum GGT levels. The general clinical data of each patient including age, height, weight, past medical history, alcohol drinking and Smoking were collected. Fasting serum was taken to measure GGT level. Pulmonary function tests were measured by one doctor specialized in pulmonary function room usingthe same spirometer. Subjects with a FEV1/FVC<70 % were identified as having COPD.SPSS 17.0 was adopted to do the statistical analysis. Measurement data were expressed as mean number±standard deviation( x ± s). Count data were compared by number(percentage). Relationship between the various factors and serum GGT level were expressed as regression analysis, Measurement data using linear regression, Count data were compared by Logistic regression analysis. P<0.05 meant that there was statistical significance.Result:In the 127 cases, the mean age of male patients was 68.7±9.2 years old, GGT level of total population is 24.0(17.0, 34.0) U/L, the prevalence of COPD in total population is72.4%. According GGT quartile group,FEV1% and FVC% are decreased with GGT level.From GGT quartile 1 to quartile 4, the prevalences of COPD is increased gradually.Multiple linear regression analysis revealed that increase of serum GGT had a significant association with decreased of FEV1% and FVC%, even when traditional Confounding factors such as age, height, weight, smoking and drinking status were adjusted. Logistic regression analysis revealed that increase of serum GGT had a significant association with increased of The risk of suffering from COPD, even when Confounding factors such as age,height, weight, smoking and drinking status were adjusted.Conclusion:GGT is closely related with pulmonary function in male patients,with the elevated GGT levels, FEV1% and FVC% gradually declined,the COPD risk gradually increased.Therefore, serum GGT levels can be used to detect male populations who are at high risk of decreased pulmonary function. And GGT as an early prediction biochemical indicator of COPD has an important range of value.