Changes Of Serum Surfactant Protein D In Patients With Bronchial Asthma Or Chronic Obstructive Pulmonary Disease And Its Diagnostic Value

Objective:To investigate the changes of serum surfactant protein D(SP-D) in patients with bronchial asthma or chronic obstructive pulmonary disease and its clinical significance in differential diagnosis of both disease.Methods:From November 2013 to April 2014 in respiratory medicine of Feng Yang hospital in Shanxi province,50 cases of acute exacerbations of COPD and 50 cases of acute bronchial asthma were enrolled in this study,and then they were divided into smoking subgroup and non-smoking subgroups,respectively.A detailed clinical and laboratory examination, pulmonary function testing by spirometry, and other related date were collected.Blood sample were obtained from each group in acute exacerbations and stable stage of both diseases.The level of serum SP-D was assayed using ELISA.The changes of serum surfactant protein D(SP-D) in patients with bronchial asthma and chronic obstructive pulmonary disease in acute exacerbations and stable stage were observed.Fifty healthy sex and age-matched subjects were enrolled as controls.The differences of serum SP-D level was compared between patients in the different diseases phases and controls and between COPD and bronchial asthma.Results:1. In the same subgroups of COPD, the level of serum surfactant protein D in acute exacerbations stage was obvious increased than in stable stage,,with significant differences(P<0.05). 2. In the same subgroups of bronchial asthma, the level of serum surfactant protein D in acute exacerbations stage was significant higher than in stable stage,,with significant differences(P<0.05). 3. In the same subgroups,compared with acute asthma,the level of serum surfactant protein D(SP-D) was higher in acute exacerbations COPD. 4. The level of serum surfactant protein D(SP-D) was significandy higher in patients with stable COPD than in asthma Patients,with significant differences(P<0.05).While The level of serum surfactant protein D(SP-D) was not significantly different between asthma and healthy controls.Conclusion:SP-D is an important factor in inflanunatory mechanisms of asthma and COPD.The serum surfactant protein D(SP-D)may be used as one of the most important biomarkers to differentiate patients with COPD from those with asthma.