Clinical Observation Of Chronic Obstructive Pulmonary Disease With Acute Exacerbation Of Ultrasonic Atomizing Inhalation Budesonideacute

Objective:To explore chronic obstructive pulmonary disease(copd) acute exacerbation period(AECOPD) inhaled budesonide and intravenous drip of the clinical effectiveness of methylprednisolone, blood gas index, drug untoward effect and hospitalization days and cost, so as to provide theoretical guidance for clinical more effective in the treatment of AECOPD.Methods:121 patients with AECOPD hospitalized pationts of the first hospital of Shanxi Medical University were enrolled in this obviousion, According to the use of glucocorticoid hormone, the patients are assigned to A group treated with low dose(3mg/d)budesonide( 33 cases), B group cured with, mdgadose(6mg/d) budesonide(32 cases),C group cured with methylprednisolone(40mg/d,28 cases) and D group not treated with any glucocorticoids( 28 cases).In the four groups, the patients’ clinical efficiency, blood gas analysis, adverse reactions, the number of days and inpatient hospitalization expenses were studyed and statistically analyzed.Results:A, B, C groups of the total clinical efficiency were higher than D group,and the differences were Clinical significance(P<0.05).There have no means(P>0.05) among A,B,C groupsAfter the treatment of blood gas index,compared with D group, A, B, C groups’ Pa O2,all increased and PCO2 decreased lower than C group, and the difference had clinicalsignificant(P<0.05)..Compared with A group,B,C groups’ Pa O2 increased and PCO2 decreased, all the difference had statisticalclincil significance(P<0.05).There had no means(P>0.05) between B,C groups.The drug untoward effect of A, B, D groups is lower than C group, and the difference was clinical significant(P<0.05).A, B, C groups of length of hospital stay and medical cost were ruduced than D group,and the differences were clinical significant(P<0.05). Compared with A group, length of hospital stay and medical cost of B, C groups were reduced, and all the difference had clinical significance(P<0.05). There have no means(P>0.05) between B,C groups.Conclusions:It came to the result that the inspiratory budesonide 6mg /day therapy is very effective,and it reduces the side effects,and the medical costs.We got the clonclusion through the treatment of AECOPD clinical curative effect and health economics.The way that It observed different doses of Budesonide inhalation and used of systemic glucocorticoid.