Distribution And Antibiotic Sensitive Rate Changes Of Bacteria Isolated From Cerebral Spinal Fluid In Neurosurgical Nosocomial Intracranial Infection

Objective:To determine the distribution of bacteria isolated from cerebrospinal fluid and sensitive rate changes of common antibiotics of the intracranial infection in neurosurgical patients, and to provide evidence for experience in using antibiotics treatment of the intracranial infections.Methods:By using HIS system,Information on cerebrospinal fluid culture positive specimens After surgical intervention in patients with intracranial infectionin Department of Neurosurgery of First Hospital of Shanxi Medical University was retrospectively analyzed from Jan 2012 to Dec 2014,and strain types,quantity,sensitive drugs and resistant drugs data of cerebrospinal fluid culture were analyzed.Results:71 strains of pathogenic bacteria were isolated from the cerebrospinal fluid in the past 3 years,and including 45 gram positive strains(63.3%), mainly for coagulase negative staphylococci, which is high resistance to piperacillin and penicillin, is only almost sensitive to vancomycin and linezolid,and only 1 strain isolated in 2013 enterococcus faecalis resistant to vancomycin,and including 25 strains of gram negative bacteria(35.2%),which is increasing trend year after year,including penumoniae 14 strains,acinetobacter baumannii 6 strains,among them with penumoniae resistant degreeincreasing gradually and acinetobacter baumannii appearing pan-drug-resistant.Conclusions:Gram-positive bacteria with intracranial infection after surgical intervention still accounts for the main part, but Gram-negative bacteria is increasing year after year.When we are experience in using antibiotics, combination should be cautious.To prevent the increase of drug resistance in patients with itself dysbacteriosis, and reduce the risk of bring patients with poor prognosis.