Distribution And Drug Resistance Analysis Of Bacterial Isolates From Ricu Patients' Of Nosocomial Infection Cases

Objective: RICU is a place where nosocomial infection(NI)often occurs. Investigate the distribution and drug resistance spectrum of clinical isolates of NI bacteria in RICU to indicate the rational use of antibiotics.Methods: Collected clinical isolates of NI bacteria in RICU from 2007 to 2008. Bacterial isolates were identified and analyzed by VITEK and ATB. SPSS16.0 was applied for analysis.Results: In the past two years, the main pathogenic bacteria of NI were Gram-negative(G-) bacteria,accounted 87.9%,87.7% respectively each year. Acinetobacter baumannii and Pseudomonas aeruginosa took the main places of the NI bacteria, about 45%. In 2008, Acinetobacter baumannii became the main pathogenic bacteria of NIs, and had a multidrug-resistance phenotype. The rest G- bacteria's drug resistance rates increased significantly, especially in penicillins and cephalosporins. No significant change in constituent ratio of Gram-positive (G+) bacteria, about 12.2% every year. The drug resistance rates reduced a bit.Conclusion: The same as other literatures, G- bacteria took the main place of the NI bacteria in our RICU. For the drug resistance rates increased in 2008, clinical doctor have to monitor distribution and drug resistance spectrum of bacteria and choose antibiotics reasonably. Besides, paying more attention to the sterilization,strengthening the aseptic concept of medical staffs,isolating the infectious patients and enhancing the supportive treatments do make sense to prevent cross-infections, and nosocomial infections.