The Clinicpathological Features And Prognostic Factors Analysis Of GEP-NEN Cases

Objective By analyzing various factors in GEP-NEN cases including the clinicpathological features, immunohistochemical expression, pathological grading and prognosis, this paper aims to promote further understanding of GEP-NEN and provide precise foundation for clinical treatment and prognostic judgment.Methods The clinicpathological documents of 119 GEP-NEN cases were analyzed retrospectively. In addition, Kaplan-Meier method was adopted to do survival analysis. Besides, Multi-factor Cox regression analysis was employed to screen independent risk factors which impacted on the survival time of patients.Results There were 72 male cases and 47 female ones among the 119 GEP-NEN cases, with proportion of male and female being 1.53:1. Ages of onset ranged from 19 to 86, with a median age of 53 and an average age of 56.2. There was statistical significance in the different ages of onset between male and female(P=0.013), with lower ages of onset of GEP-NEN among women compared with men. Pancreas was the most common site of onset(45/119, 37.82%), followed by rectum(33/119, 27.73%). And 32 of the 119 cases are functional, 87 nonfunctional.The pathological grading of 119 GEP-NEN cases was as follows: there were 76 cases of G1(63.9%), 24 cases of G2(20.2%), 19 cases of NEC(G3) which constituted 15.9%. The NEC cases included 4 large cell carcinomas, 3 small cell carcinomas and 12 MANECs. Factors such as nerve and vessel invasion, lymph node metastasis and tumor size were closely related to the pathological grading of GEP-NEN(P<0.05-0.001), while the age, gender and tumor site of the patient were relatively irrelevant. The median follow up time of all patients was 18.9(0.1-133.4) months, during which 13 of the 119 cases(10.92%) died. The results of the multi-factor analysis revealed that the pathological grading, nerve and vessel invasion and gender were independent risk factors which exerted effect on the survival time of patients.Conclusions GEP-NEN can occur in any part of the digestive system, with pancreas being the most common one. GEP-NEN has no specificity in clinical manifestation, and diagnosis mainly relies on pathological examination. Pathological grading, nerve and vessel invasion and gender are key factors in judging prognosis of GEP-NEN.