| Object:Ischemic stroke homocysteine and vascular stenosis CorrelationMethods: During the hospital 2013.5.20 ~ 2014.5.20, Yan’an University Affiliated East care patients with ischemic cerebrovascular disease and cerebrovascular disease hospital inpatient neurology ward three, collecting the number of cases 58 cases, including 40 cases of male patients, 18 cases of female patients, mean age 54.8 ± 10 years, median 54 years. Collected objects are in line with the fourth national conference of cerebrovascular disease diagnostic criteria for various types of cerebral vascular disease. General information collection included objects, including age, sex, work, hypertension, arrhythmia, diabetes, other concomitant diseases, smoking, drinking, family history of ischemic stroke. Collecting serum markers: FBG, TC, TG, LDL, HDL, folic acid, vitamin B12. For patients with ischemic stroke in the first two days of admission, the Brain MRI, using Siemens 3.0T superconductive MRI dual gradient instrument checks include: TWI1 sequence, TWI2 sequence, FLAIR sequences, DWI sequence, MRA vascular Series other conventional image, while giving neck vascular ultrasound, echocardiography, excluding cardiogenic embolism, using TOAST classification definite diagnosis of the cause. 7 days after giving no contraindications were ischemic cerebrovascular whole cerebral angiography(DSA), the Siemens operating system measured lesion stenosis rate. While the included objects are grouped, with HCY> 15 mmol / L is diagnostic criteria, divided HHE group(42 cases), including 30 males and 12 females; to HCY≤15mmol / L divided NHCY group(16 cases), 15 males and 1 female.Results:1.Ischemic stroke patients with normal homocysteine group with high homocysteine group general information. Sex between the two groups(M / F: 10/6 cases / 30/12 cases; χ2 = 0.432, P = 0.511) and age(≥40 / <40 years: 15/1 cases / 40/21 cases; χ2 = 0.052, P = 0.819) no significant difference; smoking(yes / no: 10/6 cases / 24/18 cases; χ2 = 0.137, P = 0.711) and alcohol consumption(yes / no: 5/11 cases / 10/32 cases; hypertension(yes / no; χ2 = 0.335, P = 0.563) and other lifestyle no significant difference: 7/9 cases / 32/10 cases; χ2 = 5.535, P = 0.019) were significantly different between the two groups; coronary heart disease(yes / no: 2/14 cases / 5/37 cases; χ2 = 0.004, P = 0.950) and family history of ischemic stroke(yes / no: 3/13 cases / 5/37 cases; χ2 = 0.456, P =0. 499) were not statistically different between the two groups. 2.Ischemic stroke patients with normal homocysteine group with high homocysteine group of related biochemical data available. Triglyceride(TG: 1.57 ± 0.866 mmol / L / 1.61 ± 0.738 mmol / L; t = 0.179, P = 0.845), total cholesterol(TC: 3.86 ± 0.861 mmol / L / 4.03 ± 1.030 mmol / L; t = 0.575, P = 0.586) of high-density lipoprotein cholesterol(HDL-C: 1.00 ± 0.446 mmol / L / 0.98 ± 0.245 mmol / L :t = 0.256, P = 0.79) and low-density lipoprotein cholesterol(LDL-C: 2.46 ± 0.873 mmol / L / 2.52 ± 0.739 mmol / L: t = 0.277, P = 0.738) were not statistically significant between-group differences. Folic acid(FOL: 12.41 ± 6.044 nmol / L / 8.02 ± 5.023 nmol / L; t = 2.083, P = 0.007) and vitamin B12(VB12: 179.50 + 82.443 pmol / L / 110.90 + 40.645 pmol / L; t = 4.119, P = 0.000), homocysteine(HCY: 11.04 ± 2.454μmol / L / 30.37 ± 14.706μmol / L; t = 8.220, P = 0.000) were statistically significant differences between groups. 3.Ischemic stroke patients with normal homocysteine group with high homocysteine missing group stenosis rate(by cerebral angiography) comparison. NHCY group(7 cases without stenosis, stenosis 9 cases), HHE group(no stenosis in 6 cases, 36 cases of stenosis), χ2 = 4.214, P = 0.040, statistically significant difference between groups(P <0.05). 4.Ischemic stroke patients with normal homocysteine group compared with high homocysteine group cerebrovascular stenosis rate. NHCY group stenosis rate 69.06 ±33.735%, HHE group 70.31 ± 31.830%,(t = 0.139, P = 0.890), no statistically significant difference between groups(p> 0.05)Conclusion: 1.Hyperhomocysteinemia closely associated with ischemic stroke, plasma total homocysteine and blood pressure has a positive correlation with gender, age, smoking, drinking, no clear correlation between a history of stroke. 2.Ischemic stroke associated with hyperhomocysteinemia were no significant correlation with serum lipids, and low folate and low vitamin B12 negative correlation. 3.Ischemic stroke associated with hyperhomocysteinemia those with cerebral atherosclerosis and stenosis rate, a positive correlation; but no cerebral artery stenosis and significant correlation. |
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