The Study On Correlation Of White Matter Ischemic Lesions And Prospective Memory Impairment

Objective: 1. To analyze the prospective memory(PM) damage characteristics of the white matter ischemic lesions(WMIL) patients, and investigate the correlation between WMIL and PM. 2. To study whether the hypertension, hyperlipidemia, hyperhomocysteinemia, diabetes, etc. are the risk factors of WMIL, as well as whether such risk factors are associated with PM of WMIL patiens.Methods: 31 cases of WMIL diagnosed in Sino-French Department of Neurology of Gansu Provincial Hospital from July to December 2014 were enrolled, and selected 27 cases healthy people. Evaluated the time-based prospective memory(TBPM) and event-based prospective memory(EBPM) of the two groups according to the method of Einstein. Also, the extent of WMIL lesion was scored based upon skull MRI of WMIL patients. Analyzed the relevant risk factors of WMIL and the difference in TBPM and EBPM scores of the two groups. Detected the correlation between the WMIL lesion extent and impairment degree of both TBPM and EBPM.Results: 1. TBPM score of WMIL was significantly lower than control group(3.77±1.647, 4.59±1.279, t=1.734, P<0.05), while the difference between two groups with respect to EBPM score was statistically significant(4.16±2.131, 4.93±2.319, t=1.378, P>0.05). 2. The TBPM of patients group was negatively correlated to the WMIL severity score(r=-0.446, P=0.012, P<0.05). 3. Hypertension was an independent risk factor for WMIL, but there was no statistically significant difference between hypertension and normaltensive groups on TBPM score of WMIL patients. 4. In both groups, the number of patients suffering with hyperlipidemia, hyperhomocysteinemia and diabetes mellitus showed no statistically significant difference.Conclusion: 1. WMIL may increase the TBPM impairment degree in patients, without effects on EBPM. The TBPM impairment is in positive correlation with the degree of the lesions. It show that there may exist different neural mechanism for EBPM and TBPM. 2. Hypertension is an independent risk factor of WMIL,but there is no associations with the TBPM impairment of WMIL patients. 3. There is no evident relationship between the incidence of WMIL and hyperlipidemia, hyperhomocysteinemia and diabetes mellitus.