The Study Of The Relationship Between Cerebral White Matter Lesions And Rnal Function And Other Related Factors

ObjectiveTo analysis risk factors of cerebral white matter lesions (WML), and the relationship between WML and renal function.MethodsWe collected clinical data of 106 patients who were referred in geriatric department of our hospital between December 2008 and February 2010. All patients underwent brain magnetic resonance imaging (MRI) and renal SPETCT/CT. We divided subjects into the absent-mild total WML group and the moderate-severe total WML group, the absent-mild periventricular WML group and the moderate-severe WML group, the absent-mild deep WML group and the moderate-severe deep WML group according to the severity of total WML, periventricular WML and deep WML in brain MRI using The Fazekas Scale. The relationship between the severity of WML and GFR, other clinical index were analyzed by univariate analysis and multivariate regression analysis. The correlation between WML and the index of renal function were analyzed by the correlation analysis.Result1. Compared with the absent-mild total WML group, subjects in the moderate-severe total WML group were significantly older and showed more often a history of hypertension, lower Ccr, CHOL, LDLC (P<0. 05). And GFR of subjects in the moderate-severe total WML group were lower than the absent-mild total WML group (P = 0.059). Binary logistic regression analysis showed: age was an independent risk factor for WML (OR 1.179). But, GFR and Ccr were not independent risk factors for total WML.2. Compared with the absent-mild periventricular WML group, subjects in the moderate-severe periventricular WML group were older and more often a history of hypertension, higher systolic blood pressure, lower GFR and Ccr (P <0. 05). Binary logistic regression analysis showed: age was an independent risk factor for periventricular WML (OR 1.154). But, GFR and Ccr were not independent risk factors for periventricular WML.3. Compared with the absent-mild deep WML group, subjects in the moderate-severe deep WML group were older, more often a history of hypertension and cerebrovascular disease, lower CHOL, LDLC (P<0. 05). Binary logistic regression analysis showed: age, history of cerebrovascular disease were independent risk factors for deep WML (OR 1.097, 2.692). But, GFR and Ccr were not independent risk factors for deep WML.4. Compared with the absent-mild periventricular WML group, subjects in the moderate-severe periventricular WML group had lower GFR and Cc(rP < 0.05). But, GFR and Ccr of patients are not different between in absent-mild deep WML group and moderate-severe deep WML group.5. WML and the GFR, Ccr, CREA, BUN on behalf of renal function were analyzed by the Spearman correlation analysis. It founded: total WML was negative correlated with Ccr (r = -0.229); periventricular WML was negative correlated with GFR (r = -0.210) and Ccr (r = -0.247), and was positive correlated with BUN (r = 0.194). (P<0.05). But, deep WML was not correlated with the index of renal function.Conclusion1. Renal function was a possible risk factor for WML, the relation of function with periventricular WML may be greater than with deep WML.2. Age was an independent risk factor to WML (total WML, ventricular WML and deep WML). With increasing age, periventricular WML and deep WML were all more serious.3. History of hypertension was a risk factor for WML, the relationship between systolic blood pressure and WML might be more closely than diastolic blood pressure and WML. In particular, systolic blood pressure and periventricular WML was most closely.4. Cerebrovascular disease is an independent risk factor for deep WML.