Changes In Lung Function In Patients With Type 2 Diabetes And Analysis Of Influencing Factors

Objective To investigate the changes of pulmonary function(PF) of type 2 diabetic patients and its influencing factors.Method Type 2 diabetic patients in accordance with the inclusion criteria were taken as the type 2 diabetic group(100 cases). Various PF indicators were measured, the experimental tests, including fasting blood glucose, blood lipids, and BMI and glycosylated hemoglobin were made. The microalbuminuria, fundus photography, and neuron ECG examination were given, and the insulin resistance index and smoking index were calculated. The healthy people without diabetic disease were taken as the control group(40 cases). The PF changes of the two groups were compared, and a correlation analysis was made on the influencing factors in the diabetic group.Result The TLC, VC, FEV1, MEF25 and MEF50 in type 2 diabetic group were all lower than the healthy control group, while FEV1/FVC were higher; the differences were statistically significant(P<0.05). A correlation analysis was made in the diabetic group and it was found that TLC, VC, DLCO and DLCO/VA were negatively related to the course of the disease, Hb A1 C, BMI, HOMA-IR, fasting blood glucose and its complication integral, MVV was negatively related to the BMI and microvascular complications, FEV1 was negatively related to the Hb A1 C, BMI, HOMA-IR, fasting blood glucose and the complication integral, while FEV1/FVC was positively related to the BMI and its complication integral, MEF25 was negatively related to the course of the disease, BMI, HOMA-IR, and the complication integral, and MEF50 was negatively related to the course of the disease, Hb A1 C, BMI and HOMA-IR.Conclusion PF injury was existed in type 2 diabetic patients, mainly expressing as restrictive ventilator dysfunction, small airway function and diffusion function. The lung lesion may be one of the chronic complications of diabetic disease. And the course of the diabetic disease, the blood glucose level, the insulin resistance and BMI were closely related to the PF damage. Hence, the control to the blood glucose, the improvement of insulin resistance and the control of body weight will play a significant role in the prevention and treatment of PF injury.