Clinical Analysis Of The Radiofrequency Ablation For Primary Hepatic Carcinoma

Objective: To study the clinical effect and complications of radiofrequency ablation(RFA) for primary hepatic carcinoma. Methods: The clinical data of 61 cases of primary hepatocellular carcinoma(HCC) treated by radiofrequency ablation between March 2007 and March 2012 in Department of hepatobiliary surgery of Guizhou People’s Hospital were retrospectively analyzed, all cases were diagnosed with pathologically.The survival rate of 1 years, 2 years and 3 years after operation was count. Postoperative complications such as pain, fever, abdominal bleeding, infection and pleural effusion were observed. These indicators were compared with 55 cases of HCC treated by hepatic resection(RES) in the same period. Results: The 1 years, 2 years and 3 years survival rates were 77.1 %, 62.3%, 45.9 % in the RFA group. Between the subgroups, in the tumor size <3cm group,The 1 years, 2 years and 3 years survival rates were 94.7 %, 84.2%, 68.4 %. In the tumor size 3-5cm group, The 1 years, 2 years and 3 years survival rates were 87.0 %, 65.2%, 52.2 %. In the tumor size 5-10 cm group, the 1 years, 2 years and 3 years survival rates were 61.5 %, 53.8%, 23.1 %. In the tumor size >10cm group, the 1 years, 2 years and 3 years survival rates were 16.7 %, 0.0%, 0.0 %. The survival curves found by Log-Rank test show that in the tumor size <3cm group, 3-5cm group,the survival time was significantly longer than that of the tumor size 3-5cm group(P<0.05). Of the postoperative complications, 29 cases of RAF group need pain relieving treatment after operation, 33 cases occured postoperative fever, 1 case occured abdominal bleeding, 1 case occured pulmonary infection, 1 case occured pleural effusion. Compared with cases of HCC treated by hepatic resection(RES), the survival rate of the radiofrequency ablation group was similar to that of the surgical resection group, and the survival curve was found to have no statistical significanceby Log-Rank test(P>0.05). The survival curves found by Log-Rank test show that in the tumor size<3cm group, 3-5cm group and >10cm group,there was no significant difference in survival time between RAF group and RES group(P>0.05). In the tumor size 5-10 cm group, the survival time of the RES group was significantly longer than that of the RAF group(Χ2=8.341,P=0.03). Of the postoperative complications, 52 cases of RAF group need pain relieving treatment after operation, 26 cases occured postoperative fever, 24 cases occured abdominal bleeding, 17 cases occured pulmonary infection, 4 cases occured incision infection, 15 case occured pleural effusion, the difference between the two groups was statistically significant(P<0.05) Conclusion: Tumor size <5cm group, the efficacy of radiofrequency ablation is better than that tumor size >5cm group. Tumor size <5cm, radiofrequency ablation for treatment of hepatocellular carcinoma can achieve radical treatment as surgical resection, there is no obvious difference between the radiofrequency ablation and surgical resection. Tumor size >5cm,surgical resection is better than radiofrequency ablation. Compared with surgical resection, radiofrequency ablation for primary hepatic carcinoma has the advantages of less trauma, less complications and less risk.