Study Of The Relationship Between Estrogen Receptor Gene Polymorphism And The Susceptibility To Gastric Cancer Of Han Nationality In Qinghai

Objective: Distribution of Qinghai Plateau Area in Han Chinese patients with gastric cancer and healthy people ERα gene Pvu II and Xba I, ERβ gene Rsa I and Alu I single nucleotide polymorphism of(SNPs); and then to reveal Qinghai Han Chinese patients with gastric cancer is ERα gene and estrogen receptor beta gene SNPs and relationship.Methods: By collecting 2014 March to January 2015 in Qinghai University Affiliated Hospital and pathologically diagnosed as primary gastric cancer of 80 cases of Han patients, 80 patients with age, gender and ethnicity matched healthy control group collected fasting venous blood 2 ~ 3ml, each DNA was extracted by salting out method. ERα gene Pvu II and Xba I, ERβ gene Rsa I and Alu I were identified and analyzed by PCR-RFLP assay.Results: 1. ERα and ERβ polymorphic genotypes in gastric cancer group and the control group the crowd reached genetic balance, has a group representative(P > 0.05). 2. ERα gene Xba I genotypes in gastric cancer were significant differences between group and healthy group(P = 0.003).3. The genotype frequency of Pvu II and Rsa I and Alu I was not significantly different between gastric cancer and control groups(P>0.05).Conclusion: 1.ERα Xba I may have some correlation with the susceptibility of gastric cancer in the Han population in Qinghai, and it may be susceptible factor for gastric cancer in the Han population in Qinghai. 2.ERα Pvu II gene polymorphism was not related to the susceptibility of gastric cancer in the Han population in Qinghai. 3.ERβ gene Rsa I and Alu I gene polymorphisms were not associated with the susceptibility of gastric cancer in the Han population in Qinghai.