| Objective: Using 3.0T proton magnetic resonance spectroscopy(~1H-MRS) we explored the metabolic characteristics of brain tissue in chronic mountain sickness(CMS).The purpose was to probe the effects of long-term hypoxia on bio-chemical metabolism of brain cells.Methods: Collected fifteen diagnosed with CMS patients and twelve gender, age, and altitude matched normal volunteers(control group) and performed MRS scans. To analysis the features of brain chemical metabolites in CMS group and control group.Calculate the relative content of CMS group and control group’s several metabolites(including N-acetyl aspartate(NAA), choline(Cho), creatine(Cr), glutamate and glutamyl complex a peak(GLx-a), lactate(Lac)). For the MRS data within the group were compared using independent samples t-test, between groups were compared using univariate analysis of variance(ANOVA), and pairwise comparisons.Results: The results of MRS analysis: Compared with the control group, NAA / Cr, NAA / Cho in the CMS group decreased in the bilateral basal ganglia, cingulate,frontal,the difference was statistically significant(p<0.01). Glx-a/Cr, Lac/Cr increased, the difference was statistically significant(p <0.01).Conclusion: There are differences in brain metabolism between CMS group and the control group. These differences in function can help us to deeply understand the effects of chronic hypoxia on the brain. |
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