The Effect Of The Nutritional Status On Ovarian Cancer Patients

Objectives To explore the relationship between nutritional status and clinical character severity scales, treatment effect, survival rate and prognosis in those ovarian cancer. Methods 105 cases of primary ovarian cancer patients who were treated in North China University of Science and Technology Affiliated Hospital from Jan. 2005 to Dec. 2014 were analyzed retrospectively.They were divided into three groups according to PG-SGA. The patient’s medical history and clinical information, including the diagnosis of the disease, FIGO stage, pathological type, ascites, treatment and side effects, were collected;All the patients were followed with their recurrence and survival survival condition. SPSS 17.0 were used for statistical analysis.Results 1 There was difference in FIGO stage among the three groups(c2=52.630, P<0.05). Rate of advanced cancer of the well-nourished patients(11.1%) was respectively lower than that of the mildly and severely malnourished patients(64.7%, 91.4%)(P<0.07). There was difference in pathologic differentiation among the three groups(c2=37.589,P<0.05). Well-nourished group and mild malnutrition group with poorly differentiated proportion(25.0%, 20.6%) was respectively lower than those in severe malnutrition group(85.7%), and well differentiated proportion(75.0%, 79.4%) was respectively higher than those in severe malnutrition group(14.3%)(P<0.07). The incidence of ascites of the well-nourished patients(30.6%) was significantly lower than that in malnourished patients(P<0.07).The incidence of lymphatic metastasis in the well-nourished patients(30.6%) was significantly lower than that in the malnourished patients(P<0.07). There was no difference in pathological type,cancer cell in ascites and omentum metastasis among the three groups(P>0.017). 2 The rate of CR in well-nourished patients(83.3%) was higher than that in mild and severe malnutrition group( 44.1%, 5.7%), and rate of PD in well-nourished patients(2.8%) was higher than that in mild and severe malnutrition group( 14.7%, 57.2%)(P<0.07). 3 After chemotherapy, the WBC count in each group was decreased significantly comparing with that before chemotherapy(P<0.05); The WBC count was differences among the three groups patients after chemotherapy.The WBC count in,the mild-malnutrition patients(2.47±0.81) was lower than that in the well-nourished patients(3.92±1.63)(P<0.05), WBC decreased insevere malnutrition(3.76±0.33) was significantly greater than that in mild malnutrition group(3.02±0.72), WBC decreased in mild malnutrition group was obviously greater than that in the well-nourished patients(2.15±1.07)(P<0.05). During chemotherapy, the incidence of vomiting was higher in severe malnutritionwas(11.4%) than those in wellnourished group(0.0%)(P<0.017). 4 There were a higher recurrence rate(55.9%, 74.3%) in mild and severe malnutrition group than that in well-nourished patients(13.9%)(P<0.017);The average survival time in the well- nourished was longer than that in malnutrition group(P<0.05).Conclusions Patients’ nutritional status had relationship with their clinical stage and pathologic differentiation. There were higher well proportion for well differentiated in well-nourished group and mild malnutrition group than those in severe malnutrition group. The incidence of ascites and lymphatic metastasis in the well-nourished patients(30.6%) was significantly lower than that in malnourished patients. The patients in the malnutrition group had less complete remission and higher recurrence rate as well as shorter survival time than those in the well-nourished group.