The Lianhudan Burn Cream Pharmaceutical Research

Objective Purpose of the modern fast-paced life, electrical products with variety, burns, burns, and many other diseases are also going to increase. At this stage of oral medicine for the treatment a large burns to the patient, treatment time is too long, and efficacy is not too obvious, and to the wider patient burns bring great suffering, and to this end for Chinese medicine reagents a Lianhudan burns cream for the research and development is important, and in order to achieve a better treatment, and improve the value and focus of the article on a Lianhudan burns ointment is the extraction and best preparation process, an effective ingredient analysis, quality standards, as well as initial stability for the research, and has established a HPLC hydrochloric acid to the alkali by Fukuda Yusuke Photos by the linear range for the study, GC-Lianhudan burns cream ice in the measured concentrations.Methods This study mainly orthogonal testing methods, the ethanol flow extraction methods, and determine a Lianhudan burns grease the best extraction process. The process is mainly: Bark of Chinese Corktree, Coptis chinensis, Tiger stick, Milkvetch Root the tiger-income, total 3.2g, grind into a powder, and placed in the fluid, soak for 36 hours, and to be immersed after the 90 degrees Celsius in the frying 1h, on a cold to room temperature, and the built-in, filter, and collect filtrate into pending spare, in accordance with(the Chinese Pharmacopoeia 2010 edition, Appendix) with 90% ethanol to Standard Chartered return extract 3 Times, Every 1 hour extraction, the filter, the merge from wastes. The temperature reached 45 degrees, enrichment and extracts good mobility. The fluid, add the appropriate amount Satiric acid, white petroleum jelly, bee wax, food grease, and to water bath, heat, and the matrix all melted, in cold water, the built-in temperature, when the temperature drops to 60 to 65 degrees Celsius and the extracts combined, stir in the ethanol dissolved the ice, to join the pastes, and non-stop the blender, to the anointed, even color, that is. In the study, By HPLC for its effective component berberine hydrochloride, the linear range and the GC determination of borneol contents, with salicylic acid methyl ester as internal standard, the gas chromatography: DB- FFAP capillary Chromatography column, column temperature 140°C, the same temperature 200°C, hydrogen flame ion the test server, the detector temperature of 250°C. The Lianhudan burns grease composition of the Chinese medicines, such as, rhizoma coptidis, cortex phellodendri, borneol, Giant knotweed for the thin identification analysis. In the initial stability study, through the content of berberine hydrochloride chromatographic system methodology investigation determine the stability of the Lianhudan burn cream.Results Lianhudan burns cream for the preparation technology research, orthogonal pilot to the results of a study results, the best frying process program A1B1C1, the mode of operation is continuous 12 h soak for medicinal use, oil soaked, for 1h at a specific temperature adjust the oil explosives materials, the temperature adjusted to 90°C. The linear range, through the linear range, average content of different concentrations of berberine hydrochloride was 0.86 mg, RSD to 2.17%, indicates that such a program has a stability to meet creams production development requirements. In a Lianhudan burns grease standards of quality research of astragalus root, borneol, rhizoma coptidis, giant knotweed, cortex phellodendri, effective component analysis of the thin layer identification and found that Bobby and ice, a thin layer identify spots, exclusive, negative interference-free, repeating, as a Lianhudan burns grease quality standards. The GC on a Lianhudan burns grease ice concentration measured in ice, 0.0424 to 0.212mg/m L concentration of the linear relationship, R = 0.9997(n=5), recovery rate of 100.68, RSD to 1.16 %(n=9). Through the content of berberine hydrochloride in Lianhudan burn cream chromatographic system methodology to investigate that inside the range of 0.0173 ~ 0.4346mg/m L sex good, r = 0.9996(n = 6), recovery rate was 98.5%, RSD = 1.65%.Conclusions Even the Lianhudan burn cream basically stable, the content of effective components in by HPLC for the linear range of berberine hydrochloride, suggests that even the Lianhudan burn cream preparation process is stable, feasible and reproducible. By GC to determine the content of ices in Lianhudan burn cream, and The HPLC for determination of the content of berberine hydrochloride and thin layer identification of its effective component analysis, this thesis research method is convenient, accurate, reproducible and can be used for the quality control of Lianhudan burn cream. However, this time the double Lianhudan burns grease production testing of the limited time, herbal extracts stability testing cycle in the 6 months, at least in test samples herbal stability of up to 6 months. If you want to pilot a long period under conditions of Chinese herbal medicines, stability can be further extended test time; you can verify the ointment production of medicines for stability characteristics.