Studies On Correlation Between Lysyl Oxidase Gene Polymorphism And Lung Cancer And Cocorectal Cancer

Objectives Discussion susceptibility correlation between lysyl oxidase gene polymorphism and lung cancer, colorectal cancerMethods 1 Case-control study. Collect Tangshan City, Hebei Province People’s(tumor)hospitals and hospital workers by histopathology diagnosed with primary lung cancer cases a total of 200 cases, 335 cases of primary colorectal cancer cases. Not all patients before blood sampling or anti-cancer receiving radiation therapy chemotherapy, does not limit cases of gender, age and pathological staging. Routine physical examination within the same period collected from 352 hospitals in these two cases in the control group, no restrictions of gender, age, no history of cancer, and clinical signs. Discharge standards for all subjects of: having a family history of cancer, immediate family members. Case group and the control group were living in the city and county of Tangshan Han population. Epidemiological data including name, gender, age, smoking history,epidemiological data through medical records of the patient group and surface data obtained access volumes investigation, the control group with access to the volume side survey approach. 2 application of molecular epidemiology, each subject 2ml venous blood sample collection, extraction of DNA, polymerase chain reaction- restriction fragment length polymorphism analysis and gene sequencing to detect polymorphisms genotypes. 3 groups Univariate comparison of measurement data independent sample ttest to compare the rate of single-factor test with χ2. Logistic regression analysis of genetic polymorphisms associated with lung cancer, colorectal cancer. Results 1 An association occurs 1 LOX gene 473 G / A polymorphism and lung cancer, OR = 3.84,95%CI of(2.03- 7.24). An association 2 LOX gene 473 G / A polymorphism and colon cancer, OR = 2.75,95% CI of(1.25 to 6.02). An association occurs 3 LOX gene 473 G / A polymorphism and colorectal cancer is, OR = 2.74,95% CI of(1.38- 5.43). 4 in smoking packets: 1) lung cancer, non-smoking group, between cases and control groups were statistically significant(P <0.05) genotype differences, OR = 3.97,95% CI of(1.70 to9.29). Smoking group, between the case group and the control group was statistically significant(P <0.05) genotype differences, OR = 3.25,95% CI of(1.15 to 9.16). 2) colon cancer group, in the smoking group, genotype differences between cases and control groups were statistically significant(P <0.05), OR = 2.11,95% CI of(1.02 to 4.38). 3)colorectal cancer group, in the non-smoking group, between the case group and the control group was statistically significant(P <0.05) genotype differences, OR = 1.86,95%CI of(1.24- 2.80). 5 gender packets: 1) lung cancer in the male group, between the case group and control group was statistically significant difference in genotype distribution(P <0.05), OR = 3.23,95% CI of(1.53- 6.82). In the female group, between the case and control groups were statistically significant(P <0.05) genotype differences, OR =5.25,95% CI of(1.33 to 20.80). 2) colon cancer group, the female group, the genotype differences between cases and control groups were statistically significant(P <0.05), OR= 2.27,95% CI of(1.10 to 4.70). 3) colorectal cancer group, in the male group, genotype differences between cases and control groups were statistically significant(P <0.05), OR= 1.53,95% CI of(1.01 to 2.32). In women, between the case and control groups were statistically significant(P <0.05) genotype differences, OR values 樷樷and 95% CI OR =1.91, respectively, and were 2.25,95% CI(1.03 to 3.54) and( 1.11 ~ 4.53).Conclusion This study showed that LOX gene 473 G / A polymorphism and the risk of lung cancer,colon cancer and colorectal cancer-related, and then prompts LOX gene 473 G / A polymorphism of lung cancer, colorectal cancer incidence play an important role.Figure 3, Table 38, Reference 118...