Researchs Of Functional Changes On Migraine Without Aura Based On Magnetic Resonance Imaging

The human brain is so far considered to the most complex, most delicate object in the universe, which is organized into parallel, interacting systems of anatomically connected areas. The functional segregation refers that the specific region or neural cluster of brain takes charge the specific function; while the functional integration refers that everal activity of human being needs the cooperation of some different brain regions. Nowadays, brain network research is one of the hot topics in the field of neuroscience, which can investigate the connection mechanism between brain regions on the level of system, and further reveal the underlying organization of the brain. The network analysis techonology has been applied to lots of brain research, especially to the research of brain mental and nervous disorder. In recent years, the invention and rapid development of brain imaging technologies, especially magnetic resonance imaging(MRI), provide imaging tool to acquire various brain data; while complex network analysis based on graph theory provides a valuable technical means for brain network research. The current work dedicated to investigating the underlying topological organization of the brain on the large-scale brain network level, by means of functional magnetic resonance imaging(fMRI), and graph theoretical analysis, and further detect the pathophysiological mechanism of clinical brain diseases from the system level. The main works and contributions of this dissertation are as follows:1. Using Regional Homogeneity(ReHo) analysis method to measure the brain regional of significantly different between MWoA and HC. And using the correlation analysis to detect the relationship between these are significantly different areas of the brain with duration of disease. Our results showed that the ReHo value of MWoA in the cerebellum, frontal lobe, temporal lobe, basal ganglia area appeared more decrease than HC. These areas are located in the pain matrix of brain, which are closely related to cognitive and emotional functions of people. So we suggested that with the constant stimulus of pain and increase duration of disease, MWoA corresponding cognitive emotion function will be affected. In addition, we found that ReHo values of left putamen had a significant negative correlations with duration of disease. The putamen is an important part of the basal ganglia, and basal ganglia is an important network nodes of migraine disease. So we think this may be related to the physiological response of MWoA on long-term pain stimulus. The study from the network level of resting state improved our understanding of migraine without aura pathophysiological mechanisms.2. Using functional connectivity density(FCD) mapping, an ultrafast and voxel-wise data-driven approach, to measure short- and long-range FCD in MWoA patients. We found the long-range FCD value in right inferior temporal gyrus reduced significantly in MWoA group compared to HC group. The abnormal short-range FCD values in regions of left PFC, limbic system(the bilateral hippocampus), paralimbic system(the bilateral insula, right amygdala and ACC), subcortical(the bilateral putamen, caudate) comparing to HC were found. These regions covered the great majority of the pain matrix, which was closely related to headache. These results indicate that constant pain stimulation may affect the function of the pain matrix. These brain areas mainly relates to process of cognitive and emotional of pain, which suggested that female migraine patients have an instability system of cognitive and emotional. In addition, we further found short-range FCD in left frontal cortex including left middle frontal gyrus(orbital part), left middle frontal gyrus and left inferior frontal gyrus(triangular part), and left basal ganglia(BG) including putamen and caudate were significantly negatively correlated with duration of disease, indicating that the functional networks of these regions changed as the disease progressed. And FCD values can be used as a biological indicator to measure the degree of disease of MWo A.