| Objective: Referred to the diagnostic criteria, we chose AIDS fever patients respectively incloulding 60 cases out-cold and in-heat type( A group),60 cases qi-deficiency type( B group) and 60 cases belong to the pathogen in pleurodiaphragnzatic spaces( C group) as experimental groups and 30 cases each group corresponding types( a group,b group and c group)as the control group. Both the patients in experimental groups and control group received the usual treatment of Western medical. While the patients in A group were given relieving exterior and clearing heat Particle,B group patients were given Shen Qi antipyretic Particle and C group patients were given Chai Huo Dayuan Mixture. Observe the change of main symptoms and signs and axillary temperature pre and post treatment in 270 cases AIDS fever patients. Appraise the clinical efficacy and safty of relieving exterior and clearing heat Particle,Shen Qi antipyretic Particle and Chai Huo Dayuan Mixture and describe their part mechanism of action briefly to provide the clinical basis for clinical application and further research.Methods:(1) Packet and Administration 270 cases AIDS fever patients including 140 cases male and 130 case s female were observed. The experiment take the testing method incloulding simple random,convenience sampling and contrast. Referred to the inclusion criteria, we chose 270 cases AIDS fever patients totally incloulding 60 cases out-cold and in-heat type in experimental group, 60 cases qi-deficiency type in experimental group and 60 cases in experimental group belong to the pathogen in pleurodiaphragnzatic spaces as experimental groups and 90 cases corresponding types as the control group. The AIDS fever patients with out-cold and in-heat type took relieving exterior and clearing heat Particle( 3 g each bag, 10 bags each box)3 times a day, 3g each time, infused with water. The AIDS fever patients with qi-deficiency type took Shen Qi antipyretic Particle( 0.41 g each bag,50 particles s each bottle)3 times a day,5 particles each time,infused withwater. The AIDS fever patients with the pathogen in pleurodiaphragnzatic spaces took Chai Huo Dayuan Mixture( 100 ml each bottle) 20 ml each time, 3 times a day, infused with water. The control group took usual supportive treatment of the department of Internal Medicine. The experimental drugs were airtight, Shading preservated and dispatched by the first affiliated hospital of Henan University of Traditional Chinese Medicine School. Given the medicine based on the corresponding prescription made by researcher and filled in the registration form of drug giving.(2)Detection Record From the starting date of test treatment and observation, it lasts 7 days is a cycle. Observing during a cycle, measuring axillary temperature respectively by mercury thermometers in the beginning day, the 3rd day and the 7th day. Record four groups patients’ highest temperatures on the same day.We designed the traditional Chinese medicine syndrome questionnaire referring to the guiding principle of clinical research on new drugs of traditional Chinese Medicine and Clinical technology solutions to 11 provinces medicine treatment of AIDS Project(for Trial Implementation). Appraise 270 cases AIDS fever patients’ TCM syndrome integral respectively in the beginning day, the 3rd day and the 7th day. Unless strict adverse reactions, the date of observation don’t change easily as usual. The subjects were given routine examination including routine blood test, routine urine test, stool routine, Kidney functions and electrolyte inspection in the first day and the 7th day. Observing the change of routine indexes after AIDS fever patients taking relieving exterior and clearing heat Particle, Shen Qi antipyretic Particle and Chai Huo Dayuan Mixture.(3)Statistical Analysis The date was statistically analyzed with SPSS 19.0 software. P≤0.05 will be considered the difference had statistical significance. Measurement data was being statistical described with Standard deviation of sample means. Compared with the basic value, it compares differences within group before and after the treatment with paired t-test. The changes before and after the treatment were compared with ANOVA. enumeration data was being statistical described with frequency(constituent ratio). The changes before and after the treatment were compared with χ2 testing or nonparametric test.Results : 1, Measure the axillary temperatures of the 270 cases AIDS fever patients in three groups, and then appraise 270 cases AIDS fever patients’ TCMsyndrome integral respectively before the treatment. Our results show that the comparing of routine inspection results and TCM syndrome integral between the treatment group and the control group has no statistical significant difference( P> 0.05); compared with the control group, there is no statistical significant difference( P> 0.05)in the profession, age, gender,cultural degree, route of infection, CD4 value before treatment and the medication situation of the antiviral drugs of the treatment groups patients. Baseline datas in the treatment group and the control group are consistent.2、The axillary temperature of treatment groups patients all showed decreasing after treatment for 3 days 7 days. Compared with the axillary temperature before treatment, it has statistical significant difference( P < 0.05). The axillary temperature of control group patients all showed decreasing after treatment for 3 days 7 days. Compared with the axillary temperature before treatment, it has no statistical significant difference( P>0.05). The occurrence of clinical symptoms showed a significantly reduced after the treatment. Heat, cold fits, sweatiness, throat discomfort,thirsty, cough, expectorationand other related symptoms improved significantly( P< 0.05). The total effective rate of relieving exterior and clearing heat Particle treating out-cold and in-heat type of AIDS fever patients is 95.00%. The total effective rate of Shen Qi antipyretic Particletreating of qi-deficiency type AIDS fever patients is 73.33%. The total effective rate of Chai Huo Dayuan Mixture treating the pathogen in pleurodiaphragnzatic spaces of AIDS fever patients is 75.00%. The total effective rate of usual supportive treatment of Western Medicine treating in control group of AIDS fever patients is 56.67%( a group),50.00%( b group),40.00%( c group) respectively. No adverse reaction occurred during the trial.3、 Compared with the control group, the axillary temperature of treatment group patients showed a significant decreasing after treatment for 3 days 7 days( P < 0.05). Compared with the control group, the incidence rate of common clinical symptoms of treatment group patients showed a significant decreasing after treatment( P< 0.05). Compared with the control group, each adverse effects rates in treatment group have no statistical significant difference(P>0.05).Conclusion 1、 The symptoms of out-cold and in-heat type AIDS fever patients including fever,cold fits, sweatiness,headache,dizziness, cough, etc,could be relieved effectively by relieving exterior and clearing heat Particle. 2、The symptoms of qi-deficiency type AIDS fever patients including fever, sweatiness,cold fits,throat discomfort,thirsty, cough, etc,could be relieved effectively by Shen Qi antipyretic Particle. 3 The symptoms of the pathogen in pleurodiaphragnzatic spaces AIDS fever patients including fever,cold fits, sweatiness,weary,thirsty,headache,dizziness, cough, etc, could be relieved effectively by Chai Huo Dayuan Mixture. |
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