Clinical Analysis Symptoms Of The 193 Cases Of Patients With Gout

Gout is caused by purine metabolic disorder and / or reduced excretion of uric acid is a metabolic disease caused by the deposition of urate crystals is the pathological basis of induced acute gouty arthritis, most gout patients clinical manifestation is the repeated attacks of gouty arthritis, and more than a sudden attack and with severe pain,extremely affects people life. With the rapid development of social economy, the improvement of people’s living standards, changes in diet, the current domestic and foreign research shows that its incidence rate is increasing year by year and the trend of younger, and occurs in middle-aged men and postmenopausal women. Suffering from gout caused by a series of complications will increase, so the early diagnosis and treatment of gout gout can effectively improve the patient’s quality of life,reduce the risk of gout caused by as much as possible. In recent years the urate crystal examination, using advanced dual source CT at home and abroad to carry out clinical research and analysis of gout recognition technology, and used for quantitative in differential diagnosis of gout and urate crystal deposition area, but the research at home and abroad mostly focus on acute gouty arthritis onset of uric acid. The clinical symptoms caused by salt crystallization diversity data is less. Through a large number of clinical observation and performance of joint pain, joint swelling, limitation of motion, joint pain, numbness of limbs, limb cold, limbs heavy, aversion to cold, fever, joint flushing / pale fingertips, clinical manifestations of gout is not only the traditional sense of a single or multiple severe swelling of joint the pain, the clinical manifestation is multiplicity and complexity.Objective:The use of advanced dual source CT of gout recognition technology, were observed and analyzed on 193 cases of hand foot and part of the deposit of urate crystals in patients with gout,understand its main clinical manifestations,the symptoms integral, and the urate crystal imaging classification, association of clinical symptomsand uric acid salt deposition; To explore the relation- ship between clinical symptoms and blood uric acid in patients with gout;The use of Cui Gongrang professor "view of diagnosis of gout fingers" method to observethe.The use of Cui Gongrang professor "view of diagnosis of gout fingers" method to observe the specific changes of fingers,and quantify the changes of clinical symptoms,and the relationship between.Methods:A total of 193 patients with gout patients met the diagnostic criteria, 111 cases were male(58%), 82 cases were female(42%), all of the patients were from 2013 April to 2014 August. Signed informed consent, a detailed record of the patient’s name, gender, age, clinical symptoms, finger specific changes, dual source CT urate crystal imaging and blood uric acid examination, observation, recording the number of urate crystal deposition area, and quantify the finger specific changes in the data, sorting and statistical processing.Results:1.193 cases of gout patients were found in the deposition of urate crystals in both hands and feet, altogether 240 parts of urate crystal deposition. The clinical manifestations of gout patients with joint pain, joint swelling, limitation of activity is the second, joint pain, numbness of limbs, limb hair is cool. 2 according to the grouping of blood uric acid, blood uric acid between the two groups by t test, t=-16.201, P=0.000, P<0.05, the difference was statistically significant between the groups of blood uric acid; between the two groups in clinical symptom score by t test, t=-0.242, P=0.809, P>0.05, the difference between clinical symptom integral quantization group was statistically significant. 3.According to "the urate crystal deposition in the hand and foot", "urate crystals with hand and foot point" in the relationship between uric acid crystal grouping standard, divided into light, heavy, in three groups. The rank sum test analysis, clinical symptom score of severe group and mild group, there was significant difference(P<0.05), clinical symptoms quantify integral of the moderate group and mild group with difference(P<0.05), description of urate crystal deposition site count more clinical symptoms more obvious. 4.Specific changes in patients with gout finger score does not meet the normal distribution, the integral of clinical symptoms with normal distribution. Found in the Spearman correlation analysis on patients with finger changes of quantizing integral and symptom integral, integral and fingers to quantify changes in symptoms quantify integral(r s=0.661 P=0.00), P<0.05, was found to positively correlate.Conclusions:1.Clinical features of patients with gout has the characteristics of diversity, complexity, with joint pain, joint swelling, limitation of activity is the second, joint pain, numbness of limbs, limb hair is cool. 2.Gout patients with clinical manifestations and serum uric acid value had no correlation with serum uric acid, as a dynamic observation index, blood uric acid and its clinical manifestation is not very obvious, the serum uric acid level in the normal range may be clinically significant. 3.The clinical manifestation and the deposition of urate crystals in patients with gout is related to the number, the more severe clinical symptoms more urate crystal deposition parts count. 4.The clinical manifestations and finger specific changes in quanti- tative integration positively gout patients, clinical symptoms of gout patients is more serious, the finger specific changes more obviously.