Study On The Relationship Between Superoxide Dismutase And Coronary Heart Disease

Objective: To discuss the relationship between superoxide dismutase(SOD) and coronary heart disease(CHD) by detecting the level of SOD in the patients with CHD and those without CHD.At the same time, through the detection of serum total cholesterol(CHOL),triglyceride(TG),lowensity lipoprotein(LDL), high-density lipoprotein(HDL),lipoprotein a(LP a),apolipoprotein A1(Apo A1),apolipoprotein B(Apo B) levels to study the relationship between the different types of lipoprotein and CHD.Methods: Choosing 183 cases of suspected CHD hospitalized patients in Yi Ji Shan hospital of Wannan medical college cardiovascular department from July 2014 to October 2014 as the research object,among which 108 were male, 75 were female. The average age is 62.96 ±10.59. All these patients had coronary angiography(CAG) examination. According to the results of CAG,patients was divided into control group and CHD group. On the basis of clinical classification, the CHD group was divided into stable angina pectoris(SAP) group and acute coronary syndrome(ACS) group. According to Gensini scores,quantitatively grading the degree of vascular lesions in patients with CHD. Meanwhile,detecting the level of serum SOD,CHOL,TG,LDL, HDL,LP a,Apo A1,Apo B. Besides, analyzing the general clinical data of patients, including age, gender, diabetes, hypertension, etc. Using SPSS 16.0 statistical software to handle all data.The comparison among groups was on the basis of X 2test.Measureme-nt data with normal distribution was showed with x ±S, and those did not conform to the normal distribution was showed with range interquartile. Then spearman correlationanalysis was used to analyse the relevance. Variance analysis or nonparametric test were used to compare the difference among the 3 groups. According to the results of single factor analysis, factors of P<0.10 was put in multiple factors classification Logistic regression model to investigate the related risk factors of CHD. There was Statistical significance if P<0.05.Results: 1.There were 94 patients in CHD group,including 57 cases of male and 37 cases of female. The average age was 63.91±10.34; In the SAP group, there were 23 male and 23 female. The average age was 63.0±10.0; In the ACS group,there were 34 male and 14 female. The average age was 64.8±10.7. Control group(patients without CHD) has 89 patients, including 51 male and 38 female. The average age was 61.96 ± 10.82,There was no significant statistical difference in gender, age and hypertension among 3 groups(P>0.05). 2. SAP group serum SOD was 103.1±13.2U/ml. ACS group serum SOD was 94.1±19.9U/ml. Control group serum SOD was 107.1±19.6U/ml. There was no statistically significant difference of SOD level between SAP group and control group. However,there was statistically significant difference of SOD level among 3 groups(P<0.05). 3. Level of CHOL in the control group was 3.9±1.5mmol/l and ACS group was 4.4± 0.9mmol/l.there was statistically significant difference(P<0.05); The control group level of LDL is 2.2±1.4mmol/L and ACS group was 2.5±0.8 mmol/l. there was statistically significant difference(P<0.05); The control group level of LP(a) was 129.6(81.4-269.4) mg/l, SAP group level of LP(a) was 221.3(130.2-336.4)mg/l and ACS group is 190.5(140.0-253.9)mg/l. There was statistically significant difference(P<0.05) in 3 groups comparasion. However there was no obvious statistical significance difference among 3 groups in the level of TG,HDL,Apo A1 and Apo B. 4. Serum SOD level of CHD group was negatively correlated with Gensini scoreand age, R:-0.238,-0.57, P<0.05; It was found that serum level of SOD was negatively correlated with the level of LP(a) by spearman correlation analysis(P<0.05). 5. CHD group’s SOD level of male was 97.9±18.95U/ml, female’s level of SOD was 99.43 ±15.07U/ml, the SOD level of CHD group with hypertension was 99.2±16.02 U/ml and the SOD level of CHD group without hypertension was 96.9±20.84U/ml, There was no statistically significant difference. SOD level of CHD group with diabetes was 86.2±21.35U/ml and the SOD level of CHD group without diabetes was 101.2±15.34U/ml.Compared with other side, There was statistically significant differen-ce(P<0.05). 6. Age, gender, SOD, CHOL, LDL, Apo B, LP(a) and other factors were put in multiple factors classification Logistic regression model. Results indicated that the level of SOD in patients of ACS group was lower than the control group in the level of SOD, P<0.05, the decrease of SOD was a risk factor in the prediction of ACS.Conclusion:1. Serum SOD is reduced in group of CHD, in acute coronary syndrome, the level of SOD can reduce further. 2. Serum SOD is negatively correlated with Gensini score, SOD will reduce further with the aggravation of coronary artery lesion. 3. Serum SOD is negatively correlated with the growth of the age,diabetes and the level of LP(a). It points out that diabetes,age and LP(a) are related to oxidative stress. They are risk factors in the occurrence of atherosclerosis.