The Study On The Relationship Between Serum ERK1/2 And Cognitive Impairment After Ischemic Stroke

[Objective] By collecting the patients with new cerebral infarction and their serum levels of extracellular signal-regulated kinase 1/2 (ERK1/2) volume, collecting general information, and evaluating cognitive function in patients through Mini-Mental State Examination(MMSE),Montreal Cognitive assessment(MoCA) and Wechsler Memory Scale(WMS),to explore the relationship between serum ERK1/2 and cognitive impairment after new cerebral infarction.[Methods] All cases were form the department of Neurology, the Second Hospital of Kunming Medical University.80 cases of hospitalized patients from July 2014 to January 2015 were collected, and 40 cases with new cerebral infarction (infarction group),40 cases without cerebral infarction (non-infarction group).To Record general condition of the patients including gender, age, height, weight, hypertension/diabetes/hyperlipemia history, smoking/drinking history and years of education, National Institutes of Health Stroke Scale(NIHSS) score in patients of infarction group were recorded.All selected patients were collected venous blood in the next morning, to determinate total ERK1/2 and serum glucose, triglyceride, cholesterol, low density lipoprotein and high density lipoproteins All selected patients performed conventional cranial MRI (T1-weighted images, T2-weighted images and fluid-attenuated inversion recovery sequences and diffusion-weighted Imaging) as well as the Vascular ultrasound of the neck. All selected patients were required to carry out and complete the MMSE, MoCA and the Wechsler Memory Scale to cognitive the function of cognitive and record the score. Using statistical software SPSS 17.0 compared two groups of areas of cognitive function score and the difference, and analyzed the correlation with ERK1/2.[Results] By cooperating and analyzing the general information on general aspects of infarction group and the non-infarction group as a whole, we found that age, the educational level, hardening of the arteries, plaque, diabetes and triglyceride, total cholesterol, HDL had statistical differences(P<0.05),and the atherosclerosis, plaque formation and HDL had significantly different(P<0.01); MMSE, MoCA and the MQ scores on experimental group are below the non-infarction group, every project scores of MMSE in infarction group were lower than those in the non-infarction group, and had statistical differences(P<0.05),and the orientation, memory capacity and copy graphics had significantly different(P<0.01), every project scores of MoCA in infarction group were lower than those in the non-infarction group, except for depending on space and ability to execute and naming, the attention, language, abstract, delayed recall and orientation ability had statistical differences(P<0.05)and also the significantly different(P<0.01). MMSE scores in different infarction region of scores from high to low was that:thalamus> basal ganglia region> brainstem> temporal lobes> frontal lobes, MoCA scores in different infarction region of scores from high to low was that:temporal lobes> thalamus> frontal lobes> basal ganglia region> brainstem, and MQ scores in different infarction region of scores from high to low was that:basal ganglia region> temporal lobes> brainstem> thalamus> frontal lobes, But there were no statistical differences(P>0.05); Serum total ERK1/2 concentrations in infarction group were significantly higher than those in the non-infarction group, had statistical differences(P<0.05)and the significantly different(P<0.01), serum total ERK1/2 concentrations and MMSE scores drive a negative correlation, had no statistical differences(P>0.05), serum total ERK1/2 concentrations and MoCA/MQ scores drive a negative correlation, and had statistical differences(P<0.05).[Conclusions] Cognitive impairment in patients with cerebral infarction was more severely than non-cerebral infarction. Cerebral infarction was a risk factor for cognitive impairment. After cerebral infarction, the levels of serum ERK1/2 in patients had elevated, associated with cognitive impairment, and its negative correlated with the degree of cognitive impairment. Tip ERK pathway may be one cause of cognitive function in cognitive impairment after stroke.