Evaluate The Carotid Elasticity And The Change Of Left Ventricular Systolic Function In The Patients With Head And Neck Tumor After Radiotherapy

Part I Echo-tracking technique in assessment of carotid elasticity of the patients with head and neck tumor after radiotherapyObjective: To explore the clinical value of E-tracking technique in assessment of carotid elasticity of the patients with head and neck tumor after radiotherapy.Methods: 75 cases of head and neck cancer patients after radiotherapy(radiation group) and 65 cases of healthy volunteers(control group) were enrolled in this study to compare two groups of the parameters of the carotid artery.Radiotherapy group of 39 patients were comparison of carotid artery parameters before radiotherapy and after radiotherapy.E-Tracking parameters include carotid artery stiffness parameters(B),pressure-strain elastic modulus(Ep), compliance(AC),pulse wave velocity(PWVβ) and carotid artery intima-media thickness(IMT).And analyze the injury factors of carotid artery after radiotherapy.Results: Compared with control group,β,Ep,PWVβ,IMT in radiotherapy group increased, AC decreased(all P<0.05).After radiotherapy,the β,Ep,PWVβ was higher,AC was significantly lower(P<0.05) than those in the before radiotherapy group,but IMT had no statistical significance(P>0.05). Logistic regression analysisshowed that age(>60 years), time interval of radiotherapy(>5 years) in patients with head and neck tumor after radiotherapy is the risk factors of arterial injury.Conclusion: The carotid elasticity after radiotherapy in patients with head and neck tumor decreased compared with healthy subjects. E-Tracking parameters can reflect early carotid elasticity of abnormal changes. Age, time interval of radiotherapy is the risk factor of arterial injury after radiotherapy in patients with head and neck tumor.Part II Evaluation of carotid artery elasticity and left ventricular systolic function in patients before and after radiotherapy with head and neck neoplasm by wave intensityObjective: To explore the value of the wave intensity(WI) technique in evaluating the change of carotid artery elasticity and left ventricular systolic function of the patients with head and neck cancer after radiotherapy.Methods: 39 cases of pathologically proven patients with head and neck malignant tumor were enrolled in the observation team and took WI examination before and after radiotherapy. Meanwhile using the conventional ultrasound measure values before and after radiotherapy: intima-media thickness(IMT) of carotid, resistance index(RI), pulsatility index(PI), left ventricular ejection fraction(LVEF), peak early diastolic velocity(E) and late diastolic velocity(A).The parameters were compared between the two groups.Furthermore,relationship between W1 and LVEF,W2 and E/A were analyzed by pearson correlative analysis.Result: W1, W2, β, Eρ, PWVβ in group after radiotherapy increased dramatically compared with group before radiotherapy(all P<0.05),while AC in group afterradiotherapy decreased significantly(P<0.05). The result showed no significant diference in NA, IMT, RI, PI, LVEF, E / A between two groups(all P> 0.05).We could also find a positive correlation between IMT and β, Eρ, PWVβeasily(r=0.870,P<0.01;r=0.330,P<0.05;r=0.427,P<0.01),as well as W1 and LVEF(r=0.347,P<0.05);while no correlation was found between W2 and E/A(r=0.289,P >0.05).Conclusios : The results suggest that after radiotherapy, the carotid elasticity in patients with head and neck tumor decreases. WI technique can reflect abnormal changes of carotid artery elasticity at an early stage. What’s more, WI technique may also provide an reference value on evaluating the corresponding left ventricular systolic function changes of patients after radiotherapy with head and neck tumor.