The Relationship Between Thyroid Nodules And Uterine Fibroids

Objective:Our study was to explore the relationship between uterine fibroids and thyroid nodules in females and to find some factors that may affect the occurrence of thyroid nodules.Methods:This study was a retrospective analysis, the object are females who came to the affiliated Sir Run Run Shaw Hospital of the general medical center for medical physical examination in July2013to December2013. The information collected in the physical examination including:age, BMI (body mass index), FBG (fasting blood glucose), TC (serum total cholesterol), TSH (thyroid stimulating hormone), with or without thyroid nodules and uterine fibroids and whether menopause. A total of634cases of data were selected.Using statistic software SPSS20.0to analyse the physical examination data of all the basic information, to compare patients with thyroid nodules and patients without thyroid nodule between the physical examination data, to compare the prevalence of thyroid nodules and TSH level in patients with uterine fibroids before and after menopause, to compare thyroid nodule prevalence and the prevalence of combined uterine fibroids according to different ages. Logistic regression analysis of thyroid nodules as dependent variable and the stepwise regression analysis of the age, BMI, FBG and uterine fibroids were carried out.Results:Comparison of the basic data revealed that patients without thyroid nodules had a lower average age than patients with thyroid nodules (43.54±7.6448.53±8.3P=0.000), with increasing age, thyroid nodule prevalence is on the rise. Patients without thyroid nodules had a lower average BMI than patients with thyroid nodules (22.68±2.8723.5±2.92, P=0.000). Patients without thyroid nodules had a lower mean FBG level than patients with thyroid nodules (4.84±0.445±0.83, P=0.002). And patients without thyroid nodules had a lower mean TC than patients with thyroid nodules (4.51±0.864.74±0.9, P=0.002). TSH level comparison was not significantly different (2.0±1.231.981.39, P=0.835).This study revealed that patients with uterine fibroids has a higher prebalence of thyroid nodule than patients without uterine fibroids (63.8%50.8%P=0.001), especially in patients before menopause (61.7%46.3%P=0.000), and there is not significantly different in patients after menopause.Thyroid nodule prevalence rate was higher in patients after menopause than in patients before menopause (71.6%53.0%, P=0.000) and uterine fibroids prevalence was higher in patients before menopause than in patients after menopause (43.2%30.3%P=0.012).After the analysis of independent factors (age, BMI, FBG, uterine fibroids) by logistic regression, it revealed that age (P=0.000OR=1.092), uterine fibroids (P=0.000OR=1.853), BMI (P=0.007OR=1.119), FBG (P=0.003OR=1.456) have some relevance with the occurrence of thyroid nodules seperately.Conclusion:1. Females with thyroid nodules were older and had higher levels of total cholesterol and BMI and FBG than those without thyroid nodules. 2. Females who suffered from uterine fibroids before menopause were more likely to have thyroid nodules.3. The occurrence of uterine fibroids and thyroid nodules has a certain correlation.