Parametrial Involement And The Related Factors In Early Stage Cervical Cancer

Objective:To evaluate clinicopathologic factors associated with paramentrial involvement in patients with early stage cervical cancer, and provide evidence about identification of patients suitable for less radical surgery.Methods:We retrospective reviewed the medical records in the Women’s Hospital School of Medicine, Zhejiang University from January2009to October2014of FIGO stage IA2-IIA2cervical cancer patients undergoing redical hysterectomy and pelvic lymphadenectomy. The relationships between the clinicopathologic factors and paramentrial invasion were evaluated by using univariate and multivariate analysis.Results:Of1000patients of cervical cancer,63patients had paramentrial involvement. Univariate analysis indicated that FIGO stage (Stage IB, Stage IIA)(P<0.001), serum SCC-Ag (P=0.004), tumor size measured by exam (P=0.006), tumor size measured by ultrasound(P<0.001), tumor size measured by CT(P<0.001), tumor size measured by MRI(P=0.002), depth of stromal invasion (P<0.001), LVSI(P<0.001), pelvic lymph node metastasis (P<0.001), involved surgical margins (P<0.001), vagina metastasis (P<0.001), uterus metastasis (P<0.001) were associated with paramentrial involvement. Depth of stromal invasion, LVSI, pelvic lymph node metastasis were independent pathologic factors for paramentrial invasion on multivariate analysis.Conclusion:Depth of stromal invasion, LVSI, pelvic lymph node metastasis were independent pathologic factors for paramentrial invasion.