Clinical Analysis Of40Cases Of Alcohol Withdrawal Syndrome

Objective:Study and analyze the clinical features of Alcohol Withdrawal Syndrome,in order to improve the level of clinical diagnosis and treatment of Alcohol Withdrawal Syndrome and decrease the missed and delayed diagnosis.Method:A total of40patiens who were diagnosed as Alcohol Withdrawal Syndrome and hospitalized in the Second Affiliated Hospital of Zhejiang University school of Medicine from January1,2008to January1,2015were retrospectively analyzed. These patients are divided into groups by alcoholism or non-alcoholism,abstinence or non-abstinence,and divided according to age groups within10years. The differences between these groups were analyzed with the two-side test of Fisher’s exact probabilities in2*2table and analysis of variance for variable values using the software SPSS19.0,with P<0.05considered statistically significant.Results:In the40patients, the most common symptom was delirium(42.5%),followed by the hallucination (27.5%), seizures (17.5%) and mild symptoms (12.5%).37.5%of patients stopped drinking voluntarily and62.5%of patients stopped drinking with Iatrogenic reasons. The Alcohol related diseases (68%), such as stroke, acute pancreatitis and alcoholic liver cirrhosis, were the majority of Iatrogenic reasons. We grouped these cases into two groups, the alcoholics and non-alcoholics. There were26patients in alcoholics group, and14in non-alcoholics group. In alcoholics group, the most common symptom was delirium(46%),followed by seizures(28%), hallucination (19%) and mild symptoms (7%). In non-alcoholics group, the most common symptom was hallucination (43%), followed by delirium(36%) and mild symptoms (21%). In those two groups, Seizure was more frequently observed in the alcoholics (P<0.05), but the differences among mild syndromes,hallucination and delirium were found no statistically significant. The alcoholics group (most of them age45-50y) is younger than the non-alcoholics group (most of them age50-55y). There were18follow-up cases. And in these cases,10patients were drinkers,8were non-drinkers. The education background, the composition of schooling were similar between those two groups. Most of patients were junior high school(7-5), followed by primary school(2-2) and senior high school(1-1),and there were no statistically significant. The working background, compared the alcoholics and the non-alcoholics groups, there were no statistically significant. And, as well as the working background, the differences among the residence of two groups were found no statistically significant. In different age groups, the difference of the delirium and seizures were found statistically significant(P<0.05), the highest delirium proportion group is age50-59y(50%), followed by age>60y(37.5%), age40-49y(35.7%),and age30-39y(20%).The highest seizures proportion group is age30-39y(40%), followed by age40-49y(35.7%). Age>50y groups didn’t have seizures patients. In our research, there were no recurrence patients.Conclusion:Stopping drinking was leading cause of alcohol withdrawal syndrome. The majority of Iatrogenic reasons which lead to stop drinking were alcohol related diseases. Alcohol withdrawal syndrome remained common group in the45-55years rural alcoholic males. Seizure was more frequently seen in the alcoholics or younger patients (<40y). Elder patients (>50y) more easily suffered delirium tremor.