The Effect Of Inhalation Anaesthetics For The Early Recovery Of Cognitive Function In Patients Undergoing Carotid Endarterectomy

Objective:To explore the effects of two kinds of inhalation anaesthetics on the early recovery of cognitive function in patients undergoing CEA.Methods:Twenty-one ASA physical Status II or III patients (aged55Y-80Y, GCS15points) undergoing CEA were randomly assigned to one of two study groups:the desflurane group (D group) and the sevoflurane group (S group). Cognitive function was evaluated with the Short Orientation Memory Concentration Test and the Rancho Los Amigos Scale in all patients at4time-points:preoperatively and postoperatively after patients reached an Aldrete score≥9at20,40, and60minutes.Results:Preoperative cognitive status was similar in the2treatment groups. SOMCT scores were significantly reduced in both groups at T20(P<0.01), and recovered to the preoperative level at T60(P>0.05). The comparison of SOMCT scores between two groups showed no significant difference (P>0.05). RLAS Grade were reduced in both groups, at T201patients (11%) in D group and3patients (25%) in the S group(P>0.05), whereas at T40all patients recovered to the preoperative level. The comparison of RLAS Grade between two groups showed no significant difference (P>0.05).Conclusion:In patients undergoing CEA both desflurane and seveflurane anaesthesia allows earlier postoperative cognitive decline but there were no significant differences between groups.