| Objective:To discuss the effect of neostigmine on postoperative recovery in children undergoing eye surgery by total intravenous anesthesia.Methods:90cases,agedl-7years old,ASA Ⅰ-Ⅱ,by intravenous anesthesia, undergoing elective eye surgery were randomly assigned to one of two groups:neostigmine group (h=44) N group and control group (n=46) group C. The dose of atropine0.01mg/kg to provide protection for inhibition of glands,dexamethasone0.1mg/kg,Ondansetron hydrochloride0.2mg/kg were administered before the Induction of anesthesia.All Children received Midazolam100μg/kg,fentanyl5μg/kg,propofol2.2mg/kg,rocuronium0.6mg/kg, then got endotracheal intubation, maintaining the aneshtia by continuous infusion of refentanyl and propofol. Rocuronium was not used after the Induction of anesthesia. Children in N group received neostigmine30μg/kg with atropine15μg/kg after spontaneous breathing recovered at an acceleromyography train-of-four ratio(TOFr) recovey of0.55. Children in group C were as blank control group. The recovery of Residual neuromuscular blockade time and the time in two groups out of operation room were recorded,as well the heart rate and blood pressure after postoperative extubation.The appearance of PONV or laryngospasm would also be recorded.Results:Children in N group recovery of Residual neuromuscular blockade time and the time out of operation room were significantly less than in C Group (P<0.05). The heart rate after postoperative extubation of children in N group was a little higher than in group C(P<0.05).PONV and laryngospasm did not appear in neither of two groups.Conclusion:Postoperative application of neostigmine may shorten the recovery of RNMB time in children undergoing rocuronium-induced General anesthesia and effectively antagonize the residual neuromuscular blockade, improve the quality and safety of recovery. |
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