Study Of Pentazocine Prevent Agitation In Children Cleft Palate Operation During The Recovery Period Of General Anesthesia

Objective To investigate the effect and safety of pentazocine to relieve the emergence agitation on children,who received cleft palate repair surgery during the recovery period of general anesthesia.Methods 60 children,ASA Ⅰ～Ⅱ,aged 1～3 received cleft palate repair surgery,were randomly divided into 3 groups(n=20):group P1,group P2 and group NS.When entering the post-anesthetic care unit(PACU),children were intravenous injected of pentazocine:0.5mg/kg(P1),0.3mg/kg(P2)and 0.9%Nacl(NS)respectively.Compared the coughing score、Ramsay sedation score、Pediatric anesthesia emergence delirium(PAED)and modified children’s hospital of eastern ontario pain scale(m-CHEOPS)of the 3 groups.Observed the changes of HR,MBP,RR,SPO2 at each time point and the incidence of adverse events were recorded as well.Using SPSS 19.0 package for data processing.Results During the recovery period of general anesthesia,the Ramsay sedation score of group P1 and P2 was significantly higher than group NS(P<0.05);cough score of group P1 and P2 was significantly lower than group NS(P<0.05);PAED score and m-CHEOPS score of group P1 was significantly lower than group NS(P<0.01),group P2 was lower than group NS,but have no statistical significance(P>0.05).There was no significant difference in recovery time and the adverse reaction between the 3 groups(P>0.05).Conclusion Post-operation,inject pentazocine can effectively reduce the incidence of agitation during the recovery period of general anesthesia on children who received cleft palate repair,and the children in the recovery period was more stable and safer,the recommended dose of pentazocine is 0.5mg/kg.