Expression Of C-Myc And Its Target GLS1in Peripheral T-cell Lymphoma,Not Otherwise Spsecified:a Pilot Study

ObjectiveWe investigated whether expression of c-Myc and its target GLS1could risk-stratify patients with (PTCL-NOS).MethodsIn a cohort of28patients with PTCL-NOS, paraffin-embedded samples from were collected and the levels of c-Myc and GLS1expression were determined using immunohistochemistry. We then correlated c-Myc and GLS1expression with clinical characteristics and overall survival in PTCL-NOS.Resultsc-Myc and GLS1positive expression were observed in35.7%(10/28) and71.4%(20/28) of PTCL-NOS, respectively. Neither c-Myc nor GLS1expression was significantly associated with patients’age, gender, albumin, lactate dehydrogenase and Ki-67expression, P>0.05. However, c-Myc but not GLS1overexpression was significantly correlated with inferior overall survival,.P=0.015. There is positive correlation between c-Myc and GLS1expression without statistical significance (r=0.218, P=0.265).ConclusionHigh c-Myc expression is an adverse prognostic factor for PTCL-NOS.