The Influence Of Obstructive Sleep Apnea Hypopnea Syndrome On The Liver

Objective:Based on the different course and the severity of OSA in patients toinvestigate the influence of OSA on the liver.Methods:Medical records for83in-and out-patients at the First Clinical Hospital ofJilin University between January2013and march2015who were tested bypolysomnography and diagnosed the obstructive sleep apnea hypopnea syndrom,68cases of male,15cases of female, there were40persons in control group,34cases of male,6cases of female, the degree of OSA group according to theseverity can be divided into mild, moderate and severe group, according to thecourse divided into less than5years,5to10years, more than10years in threegroups, Comparison between OSA group and the control of the prevalence ofnonalcoholic fatty liver disease and liver function parameters, such as alanineaminotransferase (ALT) and aspartate aminotransferase (AST), gamma glutamyltranspeptidase (GGT), total bilirubin (TBIL), total bile acid (TBA), Comparedifferent course and severity of OSA groups with abdominal ultrasound and liverfunction parameters.10cases of severe OSA patients diagnosed by fatty liverthrough the abdominal ultrasound were randomly selected, with FibroTouchcheck and record each patient fat attenuation parameter values and effectivedetection of liver stiffness measurement. Results:1. Compared with the control group, the prevalence of nonalcoholic fatty liver disease of OSA group obviously increased, the two groups wasstat-istically significant (P<0.01).2. With the extension of course and the aggravation of the severity in OSApatients, the prevalence of nonalcoholic fatty liver disease was an increasingtrend, the difference was statistically significant (P <0.01).3. Compared with the control group, the level of ALT was not statisticallysignificant in mild and moderate group(P>0.05), the level of ALT in patientswith OSA increased in severe group, there was significant difference (P<0.01),ALT were positively correlated with the extension of course (P<0.01).4. The serum AST,GGT,TBIL and TBA levels had no statisticalsignificance in different course and severity of OSA group(P>0.05).5. The degree of fatty degeneration may reduce after CPAP treatment in thesevere OSA patients.Conclusion:1.The prevalence of OSA patients with nonalcoholic fatty liver diseasegradually increased with the aggravation of the severity and the extension ofcourse.2.OSA can cause changes of serum ALT, ALT increased as the extension ofcourse, the more obvious in patients with severe OSA.