Lingguiyufeitang Combine With Im M Unosuppressant Clinical Research On Treatm Ent Of Lung Disease Of Systemic Sclerosis

Objective Currently, with increasing patients affected lung because of Systemic Sclerosis, most of patients were worried with purely modern medicine treatment and strongly resistance. Therefore, we will choose new treatment which combine traditional Chinese medicine and modern medincine. Systemic Sclerosis(SSc) is usually complicated with respiratory dysfunction; the aim of study is, through observation the efficacy and safety of lingguiyufeitang treat interstitial lung disease of Systemic Sclerosis, to provide the basis for its clinical application.Method 60 outpatients of SSC treated in our department in t he last two year were include, randomly from which 30 cases wer e selected as the observation group and were treated with ling guiyufeitang, taking Morning and evening 200 ml, another 30 case s were taken as the control group, who took placebo orally twi ce per day as same as dose.Both groups were taking glucocortico id 10 mg, po, qd,and taking CTX 0.8,iv.drip.everymonth. Before treatment scores of pulmonary function test, scores of HRCT, sc ores of TCM syndrome diagnostic criteria were measured for all cases The criteria of therapeutically effect was set,refer to The People’s Republic of China in the pharmaceutical industry s tandards- TCM syndrome diagnostic criteria. And the efficacy o f two groups were compared, based on the criterion,which has f our level: clinical control, obvious effect, effective, ineffec tive.Result ①The clinical comparison of two groups: as for the treatment group, the total effective rate is 72.41%.As for the control group, the total effective rate is 68.97%.There was significant difference between the clinical efficacy of two groups(P<0.05).②The comparison of adverse reactions of two groups: the control group, 7 patients had adverse reactions(24.13%). The treatment group, 3 patients had adverse reactions(10.34%).The adverse reactions of two groups have statistically significant(P<0.05).③According to the scores of TCM symptom before treatment, there were obviously differences in the same group after treatment, which include the control group and the treatment group. Compared with the scores of TCM symptom between the two groups after treatment, the scores of the treatment group which especially the scores of Chest tightness, shortness of breath will better than another group(P<0.05).④The scores of the pulmonary test between two groups after treatment compared to those before the treatment were significantly improved(P<0.05).Compared with the scores between the treatment groups and the control group after treatment, there was significant differences(P < 0.05).Moreover,the treatment group after treatment in which improving the symptoms of arthroncus, such as chest pain,weakness,cough, expectoration were more significantly improved than before treatment(P<0.05).⑤The scores of CT of lung of two groups after treatment were more significantly improved than before treatment(P<0.05). Between the two groups after treatment, there were significant differences(P<0.05).Conclusion Lingguiyufeitang has comparatively good therapeutic effect on interstitial lung disease of Systemic Sclerosis, which is not only more effective, much safer, and with fewer adverse reactions, but also is an effective method for the treatment of interstitial lung disease of mixed connective tissue disease. For improving patients with lung function, the effects were better than the control group which improving on systemic symptoms, such as cough, expectoration, weakness, chest pain, it has obvious advantages, and is worthy of clinical application.