Electroacpuncture Intervention(EA) In Different Periods Of Cerebral Infarction(CI) Patients For The Influence Of- Aminobutyric Acid(GABA) In Cerebrospinal Fluid(CSF)

OBJECTIVEBy observing the therapeutic effect of electroacupuncture( EA) intervention in different periods of cerebral infarction(CI) patients for the changes of g-aminobutyric acid(GABA) in their cerebrospinal fluid(CSF),explain the relationship between GABA and the course of CI patients,so that we can judge which time to begin EA intervention is the best for the restore of GABA in CI patients’ CSF, in turn we can interpret the mechanism and the importance of early EA intervention for CI patients’ rehabilitation from the molecular level.METHODSWe had Collected 130 ACI cases which had met the inclusion criteria from the Neurology and Rehabilitation division inpatient department in our hospital, then they were randomly divided into three groups. The first one was group A(n=43) which had received the EA intervention in the first month of their course of disease. The second one was group B(n=44) which had received the EA intervention in the second month of their disease. The third one was group C(n=43) which had received the EA intervention in the third month of their disease. In addition, we had chosed 45 cases from the Rehabilitation division outpatient department to establish the control group, they were consisted of Periarthritis of shoulder or Cervical spondylosis or Lumbar disc disease or Knee osteoarthritis patients. When the A、B、C groups patients’ illness condition were stably, they were given the same treatment measures: Xueshuantong Injection 0.4g and Physiological saline injection 250 ml once a day for two weeks, Asplrin Enteric-coated Tablets 0.1g once a day for the whole course of disease, Atorvastatin Calcium Tablets 20 mg once a day. But the control group was given the needing treatment following their own disease. The EA intervention was continued for a month, we took the Enzyme-linked Immunosorbent Assay methods to measure the beginning GABA numerical, and at the ending of each month it would be measured again, the whole research was continued for 6 months,at the ending of the study,we will judge their clinical curative effect by the NIHSS score. RESULTS1.At the beginning of the research, the GABA numerical of the A、B、C groups were no statistical significant difference(P>0.05), but compared with the control group, the GABA numerical of the A、B、C groups were significantly increased(P<0.05),so we can realized that the GABA numerical in ACI patients will significantly increased.2. At the end of the first month, the GABA numerical of group A before and after the EA intervention were statistically significant(P<0.05);the GABA numerical before the EA intervention of group B compared with the beginning numerical there no statistical significance(P>0.05);before the EA of group B compared with the GABA numerical of group A after the EA, they also showed a statistical significance(P<0.05).3.At the end of the second month, before and after the EA intervention the GABA numerical of group B showed a statistical significance(P<0.05); the GABA numerical after the EA intervention of group B compared with group C’s before the EA,the difference were statistically significant(P<0.05).4.At the end of the third month, the GABA numerical of group C before the EA compared with the beginning numerical, they were statistically significant(P<0.05),compared with the numerical after the EA, they also statistically significant(P<0.05),but the numerical after the EA compared with the numerical of group B after the EA,there were no statistical significance(P>0.05).5. At the end of the 4、5、6 months, the GABA numerical of group A、B、C were statistically significant(P<0.05); it said that EA intervention in different periods played a very important role in the late GABA residual level in CSF of CI patients.6.During the time of the first half year of CI patients, the GABA numerical of group A、B、C will falling little by little following the time extended, it showed a linear correlation between the GABA numerical and the time, when the EA intervention started earlier, the falling speed would faster, while the control group had no such a relationship. CONCLUSIONS1. The GABA numerical of ACI patients will significantly increased compared with the no ACI patients. The rise of the GABA numerical has a relationship with the severity level of the disease.2. The GABA numerical will falling little by little following the time extended, but the speed may different by their physical conditions and human intervention methods.3.EA intervention can be used when the CI patients were stably, and the EA intervention started earlier, the falling speed would faster, so the clinical curative effect would better. It can decrease the course of CI patients’ rehabilitation.4. EA intervention should be started early, the NIHSS score will significantly decreased,it can promote the patients’ prognosis; on the contrary, the later, the worse.