| Objective:This essay means to analyze the clinical efficacy to IgA nephropathy patients of Qi and Yin deficiency type by the method of traditional Chinese medicine reinforcing Qi and nourishing Yin, consolidating table and cleaning pharynx based on observation, to explore the feasibility and safety of treating the IgA nephropathy by traditional Chinese medicine, providing clinical reference basis for the treatment of IgA nephropathy. Method:Selecting 60 patients with IgA nephropathy who were the hospital nephrosis internal medicine outpatient and in hospital for treatment in February 2013 to September 2014 in traditional Chinese medicine hospital of Hubei province. Randomly we divided them into treatment group and control group, 30 cases in each group, two groups of patients with conventional treatments.Experimental group on the basis of this combined with traditional Chinese medicine Qi and nourishing Yin, solid table pharynx method of treatment, and keep half a year’s clinical observation, recording all the subjects before and after treatment for 2 months, 4 months, 6 months of urinary red blood cell count, 24 hours urinary protein, serum albumin, quantitative serum creatinine, blood urea nitrogen, TCM syndrome integral, and safety indicators, using statistic method to analyze. Results: 1 Disease curative effect comparison of two groups:About experimental group 6 patients with complete response, basic ease in 11 cases, improvement in 7 cases, 6 no effect, the total effective rate was 80.0%. About control group complete response in 3, basic ease in 6 cases, 10 cases were improved, invalid in 11 cases, the total effective rate was 63.3%; The experimental group was better than that of control group(P < 0.05). 2 Traditional Chinese medicine syndrome curative effect comparison of two groups:Treatment group cured 6 cases, 12 cases had marked effect, 8 cases were effective, 4 cases were invalid, the total effective rate was 86.7%; Control group in clinical cured 3 cases, 7 cases had marked effect, 10 cases were effective, 10 had no effect, the total effective rate was 66.7%; Experimental group was better than that of control group(P < 0.05). 3 Colds comparison in a half years of two groups:Before treatment between the two groups has no significant difference(P > 0.05);About the two groups, colds are all less after treatment than before treatment, treatment group is better than that of control group(P < 0.05). 4 Traditional Chinese medicine symptom integral comparison of two groups:Before treatment between the two groups has no significant difference(P > 0.05);In the two groups there were no significant difference between after and before treatment(P < 0.05);The comparison individual symptoms after treatment between two groups, lumbar debility, god fatigue, paled complexion, dry throat, fever, cold evil had significant difference(P < 0.05), the experimental group is better than the control group; 5 Traditional Chinese medicine symptom integral comparison of two groups:Before treatment between the two groups had no significant difference(P > 0.05);In the two groups after treatment for 2 months, 4 months, 6 months compared with before treatment had significant difference(P < 0.05); Treatment for 2 months, 4 months, 6 months, the comparison between the two groups had significant difference(P < 0.05), the experimental group was better than the control group. 6 Urinary red blood cell counts comparison of two groups:Before treatment between the two groups had no significant difference(P > 0.05);In the two groups after treatment for 2 months, 4 months, 6 months compared with before treatment had significant difference(P < 0.05); Treatment for 2 months, the comparison between the two groups had no significant difference(P > 0.05), the experimental group and control group were balanced; Treatment for 4 months, 6 months, the comparison between the two groups had significant difference(P < 0.05), the experimental group was better than the control group. 7 24 h urine protein quantitative comparison of two groups:Before treatment between the two groups had no significant difference(P > 0.05);In the two groups after treatment for 2 months, 4 months, 6 months compared with before treatment had significant difference(P < 0.05); Treatment for 2 months, 4 months, 6 months, the comparison between the two groups had significant difference(P < 0.05), the experimental group was better than the control group. 8 Serum albumin comparison of two groups:Before treatment between the two groups had no significant difference(P > 0.05);In the two groups after treatment for 2 months, 4 months, 6 months compared with before treatment had significant difference(P < 0.05); Treatment for 2 months, 4 months, 6 months, the comparison between the two groups had significant difference(P < 0.05), the experimental group was better than the control group. 9 Serum creatinine comparison of two groups:Before treatment between the two groups had no significant difference(P > 0.05);In the two groups after treatment for 2 months, 4 months, 6 months compared with before treatment had significant difference(P < 0.05); Treatment for 2 months, 4 months, 6 months, the comparison between the two groups had significant difference(P < 0.05), the experimental group was better than the control group. 10 Blood urea nitrogen comparison of two groups:Before treatment between the two groups had no significant difference(P > 0.05);In the two groups after treatment for 2 months, 4 months, 6 months compared with before treatment had significant difference(P < 0.05); Treatment for 2 months, 4 months, 6 months, the comparison between the two groups had significant difference(P < 0.05), the experimental group was better than the control group. 11 Safety comparison of two groups:The comparison of the two groups before and after treatment in liver function, blood routine, stool routine, electrocardiogram(ecg)had no significant difference(P > 0.05). Conclusion:Reinforcing Qi and nourishing Yin, consolidating table and cleaning pharynx method can obviously improve the patient’s clinical symptoms and signs, reduce the patient’s colds, reduce the number of red blood cells in patients with urinary, reduce the leakage in patients with urinary protein, improve patients plasma albumin, maintain stable renal function, delay the renal failure, having high clinical value and deserving further study. |
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