Expression And S Ignificance Of C/EBPα、CK10 In Nasal Inverted Papilloma

Objective: The expression of C/EBPα,CK10 in nasal inverted papilloma(NIP) were detected in the study.Further discussed their significance in genesia,development and recurrence of NIP.Methods: Three groups including nasal cavity mucosae(NM 10 cases),nasal polyp(NP 20 cases) and NIP(30 cases) were selected in the study.Expretion of C/EBPα,CK10 were detected by immunohistochemisty PV-6000 method.Results: ① The different expression of C/EBPα and CK10 in the group of NM、NP and NIP was statistically significant.The results of χ2 are 12.285、19.893,respectively. The results of P are 0.002、0.000.② The different expression of C/EBPα、CK10 in the group of benign NIP and NIP with atypical hyperplasia was statistically significant.The results of Z are-4.267、-3.920,respectively. The results of P are 0.000. ③ The different expression of C/EBPα and CK10 in the group of NIP with recurrence and NIP with no recurrence was statistically significant.The results of χ2 are 6.531、4.565,respectively. The results of P are 0.011、0.033,respectively. ④Our result indicate that the relationship of C/EBPα and CK10(Rs =0.578,P =0.001)is direct correlation.The difference is statistically significant.Conclusion: In conclusion, the present results describe C/EBPα,CK10 expression in NIP and their possible implication in the regulation of tumor growth and differentiation. C/EBPα and CK10 production may prove useful in terms of a prognostic marker for the recurrence in nasal inverted papilloma.