The Clinical Study Of Bushenyijing Square On Kidney Essence Deficiency And Phlegm And Blood Stasis Amnestic-type Mild Cognitive Impairment

Objective:To explore the clinical efficacy of BushenYijing Square treating amnestic Mildcognitive Impairent(aMCI) and the function of protecting injured neurons induced by D-galactose. Methods:This research contains clinical and fundamental study. Firstly, the clinical part:Screening strictly 120 cases were separated randomly. One group(treatment group) eating BushenYijing Square, while the contrast group eating Donepezil, either has 60 cases. The treatment group’s dosage is 200ml, twice, lasting 6 months, while the second group’5mg everyday on once for the same time. Both of the groups were assessed on TCM Syndromes, MMSE, ADAS-cogscores in pre-study,3rd and 6th month. Secondly, the fundamental study:the neurons fostered for 6 days were divided into 5 groups(the blank one, and other groups with different medicine and dosage), regularly detecting the content of Superoxide dismutase(SOD), Glutathione Peroxidase(GSH-Px), Lactate Dehydrogenase(LDH), Malondialdehyde(MDA) and Nitric oxide(NO). Besides, testing the activity of cells through the method of MTT.Results:All cases completed the test excepting 2 treatment group patients crossed out. The differences between both groups on sex, age, levels of education and duration were not significant, As well as the differences between two groups on scores of MMSE, ADAS-cog, TCM symptom scale, While both of the groups improved symptom after 6 months. Either of the medicine had clinical security. The fundamental study:the cells’activity from different groups:the high, medium and low leveldosage groups of Bushenyijing square showed higher activity than the measured value D-galactose model group (P<0.05, P< 0.001); The content of SOD, GSH-Px was detected higher in Bushenyijing square with high, medium, low level dosage than D-galactose model group (P<0.01, P<0.001); The content of LDH, MDA and NO in the three groups showed lower than D-galactose model group (P<0.001).Conclusion:The treatment group and the positive contrast group both are good at treating aMCI, while Bushenyijing square showed better efficacy at improving TCM symptom score than Donepezil. And it had had clinical security. Bushenyijing square has the function to protect the injured neurons against the oxidizing reaction induced by D-galactose.;Objective:To explore the clinical efficacy of BushenYijing Square treating amnestic Mildcognitive Impairent(aMCI) and the function of protecting injured neurons induced by D-galactose. Methods:This research contains clinical and fundamental study. Firstly, the clinical part:Screening strictly 120 cases were separated randomly. One group(treatment group) eating BushenYijing Square, while the contrast group eating Donepezil, either has 60 cases. The treatment group’s dosage is 200ml, twice, lasting 6 months, while the second group’5mg everyday on once for the same time. Both of the groups were assessed on TCM Syndromes, MMSE, ADAS-cogscores in pre-study,3rd and 6th month. Secondly, the fundamental study:the neurons fostered for 6 days were divided into 5 groups(the blank one, and other groups with different medicine and dosage), regularly detecting the content of Superoxide dismutase(SOD), Glutathione Peroxidase(GSH-Px), Lactate Dehydrogenase(LDH), Malondialdehyde(MDA) and Nitric oxide(NO). Besides, testing the activity of cells through the method of MTT. Results:All cases completed the test excepting 2 treatment group patients crossed out. The differences between both groups on sex, age, levels of education and duration were not significant, As well as the differences between two groups on scores of MMSE, ADAS-cog, TCM symptom scale, While both of the groups improved symptom after 6 months. Either of the medicine had clinical security. The fundamental study:the cells’activity from different groups:the high, medium and low leveldosage groups of Bushenyijing square showed higher activity than the measured value D-galactose model group (P<0.05, P< 0.001); The content of SOD, GSH-Px was detected higher in Bushenyijing square with high, medium, low level dosage than D-galactose model group (P<0.01, P<0.001); The content of LDH, MDA and NO in the three groups showed lower than D-galactose model group (P<0.001). Conclusion:The treatment group and the positive contrast group both are good at treating aMCI, while Bushenyijing square showed better efficacy at improving TCM symptom score than Donepezil. And it had had clinical security. Bushenyijing square has the function to protect the injured neurons against the oxidizing reaction induced by D-galactose.