Clinical Efficacy Visia Skin Tester Objective Evaluation Qingreliangxue Co-1% Pimecrolimus Treatment Of Hormone-dependent Dermatitis

Objective:To explore joint Qingreliangxue square oral pimecrolimus (Ai Ningda) the clinical efficacy of topical ointment glucocorticoid dependent dermatitis was observed in conjunction with VISIA digital skin tester objective evaluation of traditional Chinese medicine for the disease improvement in skin lesions, skin barrier repair and condition aspect rebound effect.Methods:44 fitted to the face corticosteroid dependent dermatitis TCM diagnostic criteria and comply Fanfei wind-heat syndrome patients, according to the order of the treatment were randomly divided into two groups, one for the treatment group to another group as a control group, two groups all 22 cases. Hormonal drugs and the patient is asked to disable all suspicious skin care ingredients. Treatment and control groups were given the morning after cleansing tinidazole topical gel (hospital homemade) 1 night after wet acid lotion topical ointment Aining Da 1, and to the side Qingreliangxue oral twice daily the control group had no internal medicine continuous observation eight weeks, in the first four weeks referral, the objective of the two groups of patients lesions (facial redness, acne-like lesions, dry and scaling) and subjective feelings (pruritus) observed records, and in newly diagnosed and 4 weeks VISIA full face red skin test recording area, UV pigmentation, texture absolute score value. The first 8 weeks of follow-up, observation rebound record, recording of adverse events and loss of samples and clinical data for all statistical analyzes were performed using SPSS 16.0 software.Results:After 4 weeks of treatment, the total effective rate was 86.3%(9% cured, effective 7%, effective 10 percent) is invalid 14%; control group,54.5%(9% cured, effective in 5%, effective 5%) is invalid 45%, the difference was statistically significant (P=0.045)After treatment for 4 weeks, facial erythema score, acne-like lesions score, dry and scaling score, itching score compared with before treatment were significantly different (p=0.000, p=0.002, p=0.000, p=0.002<0.05) was confirmed by the treatment group in improving facial redness, acne-like lesions, are effective on dry and scaling and itching.After 4 weeks of treatment in the control group, facial erythema score, acne-like lesions scores compared with before treatment decreased (p=0.002, p=0.002<0.05), there are significant differences. And dry desquamation score and pruritus score lower than before treatment, but no significant difference (p=0.005, p=0.083> 0.05) confirmed that after treatment, the control group had effect on the skin lesions improve facial redness and acne-like and improve dry and scaling and itching on effect is not significant.After comparison, the two groups after treatment in acne-like lesions and itching index difference (p=0.04, p=0.049<0.05), treatment group in improving acne-like lesions and control itching better than the control group.VISIA skin test instrument measured four weeks after treatment group red zone, drop Textures absolute value compared with before, there are statistically significant (p=0.03, p=0.014) and UV spots no significant (p=0.808). The red area in the control group compared to the previous decline in absolute value, was statistically significant (p=0.004), UV spots and textures were no significance (p=0.059, p=0.145) explained improve facial redness, acne-like lesions and capillary vasodilation effect of inflammation in both groups, but in the skin barrier repair, the treatment group than the control group.After comparison, the two groups after the treatment in the red zone and the absolute value of the absolute value of index texture difference (p=0.026, p=0.03<0.05), treatment group in improving redness, acne-like lesions and other inflammation and skin barrier repair damage better than the control group.Conclusion:Qingreliangxue party for the treatment of hormone-dependent facial dermatitis TCM for the wind-heat Fanfei Permit, supplemented by basic treatment, rapid onset of efficacy, low recurrence rate, its mechanism may be related antiallergic reaction, anti-inflammatory, anti-pathogenic microorganisms, antioxidant and immunomodulatory related. VISIA skin test and doctors subjective ratings are consistent, VISIA skin tester is more objective, comprehensive, easy to operate, can be clinical application.