The Effect Of Ephedrine And Phenylephrine On Narcotrend Values

Background:Narcotrend is a new type of anesthesia/EEG monitoring system of consciousness, its acquisition by ordinary ECG electrodes on the head anywhere instant EEG analysis can provide information on a number of parameters and EEG, after analysis processing, automatic divided into A, B0-2, C0-2,D0-2, E0-2 and F0-16 installments,15 sub-class, and quantitatively converted into similar BIS index values .0-100, EEG showed little value inhibition deeper, more intuitive user can quantify understanding anesthesia and trends based on the data and images it provides.Ephedrine and phenylephrine is general anesthesia commonly used in the treatment of hypotension vasoactive drugs, studies have pointed out that ephedrine can increase BIS index, which affects the depth of anesthesia, and phenylephrine had no effect on the BIS index. Although there are anesthetized in-depth analysis and research reports, Narcotrend with BIS has a good correlation, but because Narcotrend is a new depth of anesthesia monitoring systems, using the range is not as widely through the acquisition of EEG BIS, so on ephedrine and monitoring the impact of phenylephrine on Narcotrend values, there is no relevant reports. To study effects of ephedrine and phenylephrine on Narcotred index produced in this experiment selected 76 cases of general anesthesia combined with epidural anesthesia for gastrointestinal tumor resection, research ephedrine and phenylephrine-induced after treatment hypotension Narcotrend index of impact.Methods:Selected 76 cases of adult elective laparoscopic gastrointestinal cancer surgery patients, ASAI-II level, general combined epidural anesthesia. Routine ECG monitoring in patients with burglary, open venous access, Ringer’s lactate infusion of 10ml/kg/h, row radial artery catheterization, invasive arterial pressure monitoring, Narcotrend monitor connected to the electrode leads, monitoring Tof value, OK epidural catheterization after anesthesia appears to be the beginning of anesthesia induction. Anesthesia was induced using a target-controlled infusion of remifentanil 5ng/ml. Adjust the target concentration of propofol, after staging dropped C Narcotrend period, given rocuronium 0.6mg/kg. When T4 disappear when neuromuscular monitoring, Narcotrend staging D2-E1, endotracheal intubation.Target concentration of remifentanil 4.5ng/ml, adjust propofol target concentration, to maintain the patient in D2-E1 Narcotrend staging period, if hypotension (MAP decreased by 30%of baseline), select randomized to phenylephrine 1.5μg/kg, after which 3ug/kg/h pump Note (P group) and ephedrine 0.1 mg/kg (E group) was observed MAP, HR and Narcotrend index in 2.5min,5min,7.5min, 10min of changes.Results:Meet the requirements of 50 patients in each group of 25 people, between groups within groups, the repeated measures analysis of variance statistics too, P group in 2.5min,5min mean arterial pressure, and greater than the E group; E group heart rate 2.5min,5min.7.5min, 10min rise, and greater than P group; E group Narcotrend index 7.5min, 10min increased, and larger than the P group.Conclusion:Phenylephrine can cause changes in the value of Narcotrend monitoring, and ephedrine can cause Narcotrend index rises, reducing the shallow depth of anesthesia, and the effect of the delay in its central hemodynamic effects appear.