Analysis Of Gut Microbiota Change In NAFLD Patients

The study analyzed the gut microbiota of27nonalcoholic fatty liver disease(NAFLD) cases and31healthy controls through high throughput sequencing method. By metagenomics analysis on16S rRNA gene, we found the differences of gut microbiota between the two groups. There was an increase of some pathogenic microbes like Bilophila and Escherichia, meanwhile, there was a decrease of some normal microbes participated in metabolism like Lactobacillus and Roseburia in NAFLD patients. Also, gut microecology of NAFLD patients was slightly disturbed if we observe the differences by enterotypes, which is a more general way to describe gut microbiota. Combined with the detailed changes in bacterial species and abundances, we suggest that construct healthier gut microbiota for patients could be the possible treatment for NAFLD in the future.