Expression Of Polo-like Kinase1and Its Significance In Colorectal Carcinoma

Objective:Colorectal cancer is a common digestive malignant tumor and the he incidence of colorectal cancer is No.4in the world in malignant tumors. More and more medical research focus on looking for gene markers which correlate with colorectal cancer and could be used for early diagnosis and judgment of prognosis, risk of recurrence and metastasis, even for target of genetic therapy.Recently PLK1(polo-like kinase1) is considered to closely relate with mitosis and repair of DNA damage. Many researches revealed that the over-expression of PLK1(or PLK) were found in various primary carcinoma, and indicated the PLK1is an oncogene.The purpose of this study was to determine whether PLK1is over-expressed in surgical specimens of colorectal carcinoma as compared with normal colorectal tissue and to assess its relation to TNM staging, Duke staging, age, tumor location, metastasis and prognosis by immunohistochemical method.Methods:The expression of PLK1in colorectal carcinoma was detected by S-P immunohistochemistry in94cases of colorectal carcinoma tissue and80cases of adjacent normal tissue. SPSS16.0for Windows Software was used to analyze Statistical data. Results:PLK1was positively expressed in53.2%of the colorectal cancer specimens, and negatively expressed in normal colorectal specimens. The expression level elevation in the malignant group was statistically significant compared with that of the normal group. There were no significant associations between PLK1and sex, the depth of invasion tumor position and prognosis(P>0.05). PLK1expression was significantly related to lymph node metastasis, TNM staging, Duke staging, and age(P<0.05).Conclusion:PLK1may play a key role in the hyperplasia of colorectal carcinoma, which may further lead to motivation and invasion of colorectal carcinoma cell.