Correlative Research Of The Incidence Of Preeclampsia And Artificial Insemination By Donor

Objective:To evaluate the incidence of preeclampsia after artificial insemination with either donor’s or partner’s sperm.Methods:The clinical and follow-up data of patients who received artificial insemination in women’s hospital, School of Medicine, Zhejiang University between June2012and December2013were reviewed. In women with primary infertility all pregnancies achieved by either partner or donor artificial insemination carried to birth of a fetus (>20weeks)were identified. The baseline maternal data(age, etiology of infertility, ovulation induction,numbers of cycles) and obstetric complication (gestational hypertension, preeclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy) and perinatal outcomes (multiple birth, full-term birth, preterm, abortion, male infant, low birth weight, macrosomia, birth defect) and delivery outcome (spontaneous labor, induced labor, caesarean section) were compared. Results:A total of308patients were followed, included162artificialinsemination by donor and146artificial insemination by partner’s sperm. These two groups had no statistical significance in patient’s age, multiple birth, abortion, gestational hypertension, preeclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, spontaneous labor, induced labor, caesarean section, male infant, macrosomia, birth defect(P>0.05). The male infertility, natural cycles, numbers of cycles and full-term birth of AID are significant higher than AIH (P<0.05). The female infertility, unexplained infertility, ovulation induction, preterm and low birth weight of AIH are significant higher than AID (P<0.05). Pregnancies conceived by donor insemination were more likely to have a full-term birth (OR=1.98,95%CI1.05-3.75), a induced labor(OR=1.84,95%CI0.54-6.26), a caesarean section(OR=1.15,95%CI0.73-1.83), a macrosomia(OR=1.32,95%CI0.52-3.36), and to develop gestational hypertension (OR=1.74,95%CI0.51-5.93) or preeclampsia (OR=4.37,95%CI0.53-37.88) after adjusting for multiple birth.Conclusions:There is a higher incidence of preeclampsia in women conceiving by artificial insemination by donor sperm compared with artificial insemination by partner sperm. The exposure to partner’s semen maybe protects against the development of preeclampsia.