3D Color Doppler In Hyperthyroidism (Graves Disease) Application

ObjectiveHyperthyroidism (Graves disease) is caused by too much thyroidgland produces thyroid hormones such as nerve, circulation, digestionsystem increased excitability and hypermetabolism general as the mainperformance of a group of diseases, The main clinical manifestations of theemotional symptoms and signs, heart palpitations, appetite hyperthyroidism,sweat, angular, exophthalmos, goiter, etc. With Graves disease incidencerate continue to rise in recent years, the onset age and the trend of the age[1],Therefore, to make objective and accurate diagnosis of Graves disease,early intervention in time is very important. At present, Graves diseasediagnosis mainly depends on the determination of thyroid function oflaboratory, Ultrasound can evaluate Graves from the aspects ofmorphology and hemodynamics changes in thyroid disease. Typicaltwo-dimensional color doppler ultrasound Graves disease characterized bydiffuse enlargement of the thyroid gland and abundant blood flow signals,etc, But the hemodynamic evaluation is to increase the degree of throughthe blood flow signals of the senses, indirect way through thyroid arteryflow velocity at the same time increase the semi-quantitative assessment;Color doppler signal by the instrument of two-dimensional gray-scale and color gain adjustment effect; Three-dimensional ultrasound blood flowimaging can quantitatively evaluate the degree of thyroid glands, bloodvessels, increase blood flow, make up for the deficiency of thetwo-dimensional color doppler ultrasound. This study used2d and3dcolor doppler ultrasonic inspection on Graves disease, to observe thehemodynamic changes in thyroid gland, explores the three dimensionalcolor doppler ultrasound in the Graves disease diagnosis of thyroid, bloodvessels, blood flow quantitatively.MethodsThe fellowship from55cases of jilin university hospital nuclearmedicine proposed nuclide therapy as case group in patients with Gravesdisease another random38cases of healthy volunteers as control group, allthe subjects of thyroid ultrasound. Two-dimensional ultrasoundmeasurement before and after thyroid around the top and bottom diameter,diameter, diameter, diameter, before and after the spondylolysis thyroidartery diameter, doppler ultrasonic thyroid artery flow velocitymeasurement. Three-dimensional ultrasound thyroid three-dimensionalcolor doppler image collected and stored, use the QLAB software system,the stored image3d reconstruction, and vascular index (VI), blood flowindex (FI), blood vessels, blood flow index (VFI) parameters. Applicationof case group and control group each parameter t test were analyzed, and the cases of thyroid of the left lobe and right lobe and thyroid lobe, middleand lower parts of the VI, FI and VFI were analyzed respectively. UsingPearson correlation analysis of cases before and after thyroid around thetop and bottom diameter, diameter, diameter, diameter before and after thespondylolysis, thyroid artery diameter, thyroid artery flow velocity, VI, FIand VFI in various parameters and thyroid function index FT3、FT4, TSHand24hours of high iodine absorption rate (%) for correlation analysis.Results1.2d ultrasound showed that cases of thyroid gland was increase,symmetry, and for the three lines are increasing, lateral lobes spondylolysisis normal, the transverse diameter were greater than before and after thediameter, membrane integrity, no limitations uplift, gland parenchyma echois not uniform; Thyroid artery lumen broadening.2. Color doppler showed that cases of thyroid glands color blood flowsignal is patchy, bright colors.3.3d ultrasound parameters results: the case group and control groupon the same side lobe thyroid gland VI, FI and VFI have significantdifference (P <0.01), CPT left lobe thyroid gland (bottom), which with theright lobe glands (bottom), which the VI, FI and VFI in contrast with theparts have no obvious difference (P>0.05), and cases with thyroid (the left lobe and right lobe) lateral lobes glands, middle and lower part VI, FI andVFI in no significant difference (P>0.05).4．Cases before and after thyroid around the top and bottom diameter,diameter, diameter, diameter before and after the spondylolysis, thyroidartery diameter, thyroid artery flow velocity on the parameter respectivelywith FT3、FT4,24-hour high iodine absorption rate (%) were positivelycorrelated, and negatively correlated with TSH.5. Cases of thyroid gland VI, FI and VFI was positively related withFT3, VI and VFI and FT3was significantly positive correlation; VI, FI andVFI and FT4were positively correlated; VI and VFI and negativelycorrelated with TSH, FI and TSH without correlation; VI, FI and VFI in24hours with high iodine absorption rate (%) were positively correlated.Conclusion1.3d ultrasonic blood flow imaging can quantitatively evaluateGraves disease of thyroid gland vascular expansion and the degree ofincreased blood flow.2. Each part of the thyroid gland Graves disease vasodilation andincreased blood flow to the extent of the uniform.3. Thyroid gland VI, FI and VFI in Graves disease has goodcorrelation with thyroid hormone levels. 4.3d blood flow imaging diagnosis method as a new, three-dimensional, Graves disease can be intuitive, quantitative evaluation ofthyroid blood flow case.