Meta-analysis Of Risk Factors For Affecting The Occurrence Of Gastrointestinal Bleeding In Chinese Patients With Cerebrovascular Disease

Objectives:By analyzing the risk factors for affecting the occurrence ofgastrointestinal bleeding in Chinese patients with cerebrovasculardisease,the aim of the study is to provide a basis for taking appropriatepreventive and treatment measures,thus reducing the morbidity andmortality of the cerebrovascular disease.Methods:With "cerebrovascular disease, stroke, cerebral thrombosis, cerebralinfarction, cerebral infarction, cerebral ischemia, cerebral hemorrhage"and "risk factors, gastrointestinal bleeding, stress ulcer, peptic ulcer" oneof which combine,with "keywords,MeSH, title" approach,searching thedata in Articles Database and Chinese Academic Journal from self-builtlibrary to October2014,combined with manual searches,screened theChinese study.Meta-analysis of the literature data with meting theinclusion criteria.Establish a evaluation form of the risk factors foraffecting the occurrence of gastrointestinal bleeding in Chinese patientswith cerebrovascular disease.Results:The study included23documents.There are a total of1336cases ofpatients with cerebrovascular disease complicated by gastrointestinalbleeding,28,888cases in the control group(patients with cerebrovasculardisease are not complicated by gastrointestinal bleeding).The incidence of Cerebrovascular disease complicated by gastrointestinal bleeding inpatients older than60years old was higher than in patients less than60years of age,the former occurs risk of gastrointestinal bleeding is1.47times that of the latter.The incidence of hemorrhagic cerebrovasculardisease with upper gastrointestinal bleeding was higher in patients withischemic cerebrovascular disease,the former occurs risk ofgastrointestinal bleeding is3.34times that of the latter.The incidence ofcerebrovascular disease complicated by gastrointestinal bleeding inhypothalamic lesions of the patients was higher than lesions in other partsof the patient, lesions in the thalamus of patients the risk ofgastrointestinal bleeding is5.17times that of the lesions in otherparts.The incidence of cerebrovascular disease with upper gastrointestinalbleeding in the patients with GCS score less than or equal8points washigher than the patients with more than8points,the former occurs risk ofgastrointestinal bleeding is8.02times that of the latter.The incidence ofgastrointestinal bleeding in those who had history of cerebrovasculardisease was higher than those who had no history of cerebrovasculardisease,the former occurs risk of gastrointestinal bleeding is1.43timesthat of the latter.The incidence of gastrointestinal bleeding in those whohad history of digestive diseases was higher than those who had nohistory of digestive diseases,the former occurs risk of gastrointestinalbleeding is1.80times that of the latter.The incidence of gastrointestinalbleeding in the patients with a history of alcohol consumption was higherthan non-drinkers,the former occurs risk of gastrointestinal bleeding is2.38times that of the latter,differences were statistically significant(P<0.05). However,The incidence of the disease between men and womenwas not significantly different,the difference was not statisticallysignificant (P>0.05).The incidence of gastrointestinal bleeding in the patients with history of taking aspirin or smoking was higher than thosewho had no history of taking aspirin or smoking,the difference was notstatistically significant (P>0.05).Conclusion:Older than60years old, hemorrhagic cerebrovascular disease,thalamic lesions, GCS score8points or less, history of cerebrovasculardisease, history of digestive diseases, drinking history were the riskfactors of stroke in patients with gastrointestinal bleeding.Sex, smokinghistory and the history of aspirin is not yet considered a risk factor foraffecting the occurrence of gastrointestinal bleeding in Chinese patientswith cerebrovascular disease.