The Study Of Caulis Polygoni Multiflori Dual-dose Time-controled Release Pellets

Caulis polygoni multiflori, the variety contains in Pharmacopoeia, and it can be used in health care products. This subject chose Caulis polygoni multiflori as model drug to prepare dual-dose, time-controlled pellets, which be used.in sleep improvement, such as disenchantment at midnight and morning. The main contents of my paper included six aspects.1. The technology of extraction of Caulis polygoni multifloriTaking total flavonoids and total anthraquinone in Caulis polygoni multiflori as effective parts, to optimize the microwave extraction process by central composite design-response surface methodology.2. The technology of purification of Caulis polygoni multifloriTo screen some kinds of macroporous resin by investigating the indicators of static adsorption,dynamic adsorption and adsorption curve. Then used the selected macroporous resin to purify the extractive, finding the optimum purification technology.3. The research on quality standard of the Caulis polygoni multiflori extractiveTo determine the total flavonoids and total anthraquinone in Caulis polygoni multiflori by making use of thin-layer chromatography (TLC) and UV spectrophotometry on two aspects of the nature and the quantity.4.The forming technology of Caulis polygoni multiflori time-controlled pelletsPreparing the time-controlled pellets by using the technology of fluidization, coating the medicine layer, insulation layer, controlled release layer, the medicine layer.5. The study on quality standard of Caulis polygoni multiflori dual-dose pulsatile pelletsTo establish the qualitative discrimination method of Caulis polygoni multiflori dual-dose pulsatile pellet, the quantitative assay method of the total flavonoids and total anthraquinone. Referencing the appendix of Chinese Pharmacopoeia of2010, to establish the quality standard of Caulis polygoni multiflori dual-dose pulsatile pellet.