Systematic Reviews For Short-term Effects Of Acupuncture In Treating Migraine

Objective:Trough comprehensive retrieval and bias evaluation and combined analysis, we want to explore the short-term efficiency and safety of acupuncture as a main intervention for migraine.Methods:1.Data RetrievalChinese database:CBMdisc, CNKI, VIP, Wanfang Data. English database: Pub-Med or Med-line, Embase, CETRAL. Hand searching covered the core journals in this field so far, such as 《Chinese Acupuncture》、《Traditional Chinese Medicine》, etc.2. Selective CriteriaAll randomized controlled trials published in biomedical journals that recruited participants with migraine were included. Intervention method in treatment group was supposed to be real acupuncture; intervention method in compared group can be sham, western medicine, Chinese herbs. Treatment course was supposed between20days to1month.3. Data Collection and AnalysisTwo evaluators were responsible for data extraction and article screen independently, the third evaluator verified all information. All disagreement were decided by consensus. Risk bias was assessed by Cochrane Handbook for Systematic Reviews of Interventions5.1.0, then Review Manager5.2.9and Grade-profiler3.6were adopted for Meta analysis and evidence grading.Main Result(1)22clinical trails were included, altogether1606participants,570male and1092female were reported, the average age is33.64years old. They suffering from migraine range from1year to30years.(2)6combined results from acupuncture VS western medicine:Effective rate:RR1.19,95%CI[1.13,1.25], no. of attack for1month:SMD0.75,95%CI[0.42,1.08], headache intensity:SMDO.47,95%CI[-0.17,1.10], Migraine Duration:SMDO.62,95%CI[0.46,0.78], Accompanying symptom: MD0.02,95%CI[-0.02,0.06], Symptom Score:SMDO.82,95%CI[0.45,1.20]。(3)8combined results from acupuncture VS chinese-herbs of sham-acupuncture:Effective rate:RR1.27,95%CI[1.15,1.4], no. of attack for1month:MD12.9,95%CI[0.96,1.62], headache intensity:MD0.82,95%CI[0.11,1.53], migraine duration:MD1.12,95%CI[0.49,1.75], Accompanying symptomMDl.55,95%CI[-0.06,1.16]。(4) Combined results for acupuncture VS controlled group:TCD-MCA:MD7.76,95%CI[3.65,11.88],TCD-ACA:MD1.79,95%CI[-11.99,15.58],TCD-PCA:MD5.10,95%CI[3.25,6.95], TCD-BA:MD4.26,95%CI[-0.22,8.75], TCD-VA:MD1.32,95%CI[-0.24,2.88], VAS-Score:MD2.15,95%CI[0.84,3.46], adverse effect:RR0.11,95%CI[0.03,0.49]。 Conclusions:1. Compare to western medicine, acupuncture resulted better effects in effective rate、symptom score、reduce attacks and Shorter onset-time, with the evidence ranked moderate, this outcome turned to be stable.2. Compare to chinese-herbs or sham-acupuncture:acupuncture had better effects in effective rate、reduce attacks and intensity、shorter onset-time. With the evidence ranked Very-Low to Low, they need to be treated with caution.3. Compare to controlled group, acupuncture resulted better effects in VAS-score, with the evidence ranked moderate, this outcome turned to be stable; it also had better effects to improve MCA、PCA in TCD, with the evidence ranked Low, this outcome need to be treated with caution;4. Compare to controlled group, acupuncture reported less adverse effects, with evidence quality ranked moderate, this outcome turned to be stable.