Study On The Role Of Ang Ⅱand PGI₂in Hypertensive Disorders In Pregnancy And Pregnancy Outcome

Objective: Through the detection of the different level of angiotonin II (AngⅡ) andprostacyclin (PGI2) in the serum of pregnant women of hypertensive disorders andnormal pregnant women, explore the role and significance about the two factors inhypertensive disorders in pregnancy. Through the detection of AngⅡ and PGI2in theserum of pregnant women of hypertensive disorders and normal pregnant women,decide the severity of hypertensive disorders in pregnancy, and interventions likeapplication of prostacyclin analogues can reduce the hypertensive disorders inpregnancy, especially eclampsia. By analyzing the hypertensive disorders in pregnancy,serious complications and perinatal outcome of children occurrence of seriouscomplications in order to better understand the impact of clinical HDCP on maternaland perinatal outcomes, provide a theoretical basis for clinical diagnosis and treatment.Methods: Select40cases the gestational age are between32weeks to41weeks inpatients with hypertensive disorders in pregnancy as the experimental group. Inaccordance with national textbooks seventh edition of the diagnostic criteria forgestational hypertension, we divide into gestational hypertension group and severepreeclampsia group. Select20the normal full-time pregnant women in the same periodin our hospital as a control group; Serum levels of AngⅡ and PGI2were measured by enzyme-linked immunosorborent assay (ELISA) when all the pregnant women wereadmitted to hospital, and recorded their newborns postpartum.Results:1. The levels of AngII on the team of severe preeclampsia（129.49±11.22pg/ml） were significantly higher than the team of gestationalhypertension （100.83±15.39pg/ml）, and both higher than control group（35.10±10.72pg/ml）.Their differences are significant in statistics;2. The levels of6-keto-PGFl ɑ on the team of severe preeclampsia （57.50±12.17pg/ml）were significantly lower than the team of gestational hypertension（78.00±12.98pg/ml）,and both lower than control group（96.39±13.16pg/ml）.Their differences are significantin statistics;3.40cases of patients with hypertensive disorders in pregnancy are complicated bypostpartum hemorrhage three cases, placental abruption two cases, four cases of liverdamage, kidney damage in4cases,12cases of retinopathy, no heart failure, DIC orcerebral vascular accident concurrent the occurrence of disease. The most seriousincidence of complications in three groups of pregnant women is severe pre-eclampsiagroup. However, severe gestational hypertension and preeclampsia between the twogroups showed no significant difference（P＞0.05）；4. compared small for gestational age, fetal distress and neonatal asphyxia of gestationalhypertension, severe preeclampsia group and the control group of preterm, severepreeclampsia highest incidence was significantly（P＜0.05）.Compared preterm,gestational age children of gestational hypertension and severe preterm preeclampsia,there is statistically significan（tP＜0.05）；Compared fetal distress, neonatal asphyxia ofgestational hypertension and severe preeclampsia, there is no significant difference（P＞0.05）.5. The delivery methods of gestational hypertension, severe preeclampsia and controlgroup are cesarean.There is no significant difference among the three（P＞0.05）. Themost vaginal delivery group among the three is control group. The difference was statistically significant （P＜0.05）. There is no statistical significance betweengestational hypertension and severe preeclampsia group （P＞0.05）.Conclusion:1. The levels of AngII on the team of severe preeclampsia weresignificantly higher than the team of gestational hypertension, and both higher thancontrol group. The levels of6-keto-PGFl ɑon the team of severe preeclampsia weresignificantly lower than the team of gestational hypertension, and both lower thancontrol group.Their differences are significant in statistics; So there is closelyrelationship with Ang Ⅱ, PGI2and pathogenesis of hypertensive disorders inpregnancy. Ang Ⅱ and PGI2can be used as indicators of the condition ofhypertensive disorders in pregnancy.2. The complications of hypertensive disorders in pregnancy about placental abruption,postpartum hemorrhage, the incidence of retinopathy, liver and kidney dysfunction wassignificantly higher than normal blood pressure. The largest proportion among the threeis retinopathy.3. Birth weight in pregnancy-induced hypertension is significantly lower than that innormal blood pressure. The incidence of premature birth, fetal distress, neonatalasphyxia was higher than normal blood pressure.4. Severe preeclampsia pregnancy termination based approach to cesarean section.