A Comparison Between Optical Coherence Tomography And Visual Evoked Potential In Patients With Multiple Sclerosis

Objective The aim of this study is to compare the sensitivity between optical coherence tomography(OCT) and visual evoked potential(VEP) in patients with multiple sclerosis(MS).Methods We collected15patients in acute phase of MS who were admitted to the department of neurology,the2th Affiliated Hospital of Zhejiang University School of Medicine. All of these15patients underwent Expanded Disability Status Scale (EDSS), VEP and OCT exams. Eyes were defined as optic neuritis(ON) eye with a history of ON, and non-ON eye if not. All statistical analyses were performed with SPSS statistical package version17.0.Results Retinal nerve fiber layer(RNFL) thickness, macular volume, and VEP were abnormal in12.5%,23.3%, and53.3%of all eyes,12.5%(p=0.044),12.5%(p=0.044), and75.0%in ON eyes, and13.6%(p=0.047),27.3%(p=0.210), and45.5%in non-ON eyes. Conclusion VEP is more sensitive than OCT when estimating vision pathway impairments with MS patients in acute phase.