| Objective: Hepatitis B virus (HBV) infection in different clinical outcomes, hepatitisB occurrence and development is closely related to immune status of the host cell, andperipheral blood T lymphocyte subsets is a reflection of the immune pathogenesis ofchronic hepatitis B patients one indicator mechanism, resulting in a slower change of Tlymphocytes in patients with hepatitis B through research, observation of T cell subsetsand HBeAg, HBV-DNA viral load, liver function, TCM and other elements of relevance.And research Ruangan Tang on chronic hepatitis B patients with T cell subsets. Provideclinical guidance for the treatment of chronic hepatitis B patients.Method: Clinically,80cases of chronic hepatitis B patients for the study, patientswith chronic hepatitis B records collected five (qualitative), HBV-DNA quantification, Tlymphocyte subsets, liver function and other laboratory values and syndromes, usingstatistical methods analysis of T lymphocyte subsets and other indicators of relevance;collecting records of patients using soft liver soup for12weeks after T lymphocyte subsets,using statistical methods of soft liver soup on T lymphocyte subsets.Result: There was no significant difference between the four indicators HBeAg-positive T lymphocytes and negative groups. None among HBV-DNA positive andnegative groups of four indicators T lymphocytes significant difference, four indicators ofdifferent HBV-DNA load in each group T lymphocytes was no significant difference, Pvalues were greater than0.05, Spearman correlation analysis the results showed that,HBVDNA load with four indicators T lymphocytes no correlation. Chronic hepatitis Bpatients with different ALT groups of four indicators of T lymphocyte subsets have some differences, including ALT <3UNL, ALT> CD8+, CD4+/CD8+P values10UNLgroups were less than0.05, ALT <3UNL group of CD8+value lower than ALT>10UNLgroup, ALT <3UNL of CD4+/CD8+value is higher than ALT>10UNL group, thedifference was statistically significant. Spearman correlation analysis showed, ALT valueis positively correlated with CD3+levels were (r=-0.260, P=0.022<0.05) positivecorrelation between CD8+levels were (r=0.282, P=0.013<0.05);3UNL <AST<10UNL, CD8+T P AST>10UNLB value of less than two0.05,3UNL <AST <CD8+value10UNL group than AST>10UNL group, the difference was statistically significant.AST values with CD3+levels were positively correlated (r=-0.260, P=0.022<0.05)positive correlation between CD8+levels were (r=0.282, P=0.013<0.05). Chronichepatitis B patients with different ALB, GLB groups of four indicators T lymphocytesubsets were no significant differences in the groups of T lymphocyte subsets P value offour indicators were greater than0.05, not statistically significant. Spearman correlationanalysis showed that, ALB value with CD3+levels were positively correlated (r=0.255,P=0.025<0.05). TBIL chronic hepatitis B patients with different groups of four indicatorsT lymphocyte subsets differences, TBIL≦2UNL, TBIL>5UNL two CD4+P values lessthan0.05, TBIL≦2UNL group CD4+values above TBIL>5UN group, L statisticallysignificant. Spearman correlation analysis showed that, TBIL value with CD3+levelswere negatively correlated (r=-0.403, P=0.00<0.01), and CD4+levels were negativelycorrelated (r=-0.265, P=0.02<0.05). No inter-group and the liver spleen and gallbladderdamp group four indicators T lymphocytes significantly different, and the remaining threegroups the number is too small, not statistically significant, it does not participate instatistics. There was a significant difference between pre-treatment group and the treatmentgroup four indicators T lymphocyte subsets, CD4+, CD4+/CD8+value in the treatmentgroup was significantly higher than before treatment group, treatment CD8+value of theformer group was significantly higher than after treatment group, P values were less than0.05, statistically significant.Liver function between the treatment group before and aftertreatment groups have significant difference, ALT, AST, TBIL P values were less than0.01, there was a significant statistical significance.Conclusion: Patients with chronic hepatitis B and T lymphocyte subsets ALT, AST,ALB, TBIL have some correlation with HBeAg, HBV-DNA load, no obvious correlationsyndromes, requires further study. By treating soft liver soup, can significantly improve thesituation of T lymphocyte subsets. |
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