The Scientific Data Resources Survey And Framework Design Of Subject Database Of AIDS

ObjectiveThis study aims to find out Acquired Immunodeficiency Syndrome (AIDS) related scientific data resources (scientific and technological achievements, fund projects and scientific literature) of China, and construct subject database framework of AIDS.MethodsUsing the method of Indirect Survey, we investigated AIDS related scientific data resources (scientific and technological achievements, fund projects and scientific literature) of China. And then we designed AIDS subject database framework on the basis of bibliometric analysis and information resource planning of the resources that we found.Results:1.We found a total of6AIDS-related business databases and received the number of scientific and technological achievements of1050(1988-2010), Chinese scientific literatures66,939(1983-2011), English scientific literatures10,389(1983-2011), the scientific research funds357(1999-2011).2.The results of the database resources are as follows:(1)The AIDS-related business databases are managed by the Chinese Center for Disease Control of STD and AIDS Center, and the contents focused on the monitoring of high-risk infection rate,high-risk behavior intervention, methadone maintenance treatment,and antiviral treatment and so on.(2)AIDS-related scientific and technological achievements mainly concentrated in2000-2010,a total of992items,accounting for94.4%; The greatest portion of achievements were made by colleges and universities, a total of407(39%); small scale gathering cooperative networks were found in the researchers who completed the scientific and technological achievements; AIDS-related scientific and technological achievements concentred in the following areas:basic research focused on the development of adjuvant,antibodies,ets;genetic diagnosis,drug, differential diagnosis and sexually transmitted diseases,tuberculosis and other infections were included in the AIDS clinical area;AIDS prevention and control concentred on the epidemiological studies of women,college students,drug users and other high-risk groups and AIDS prevention,intervention models such as behavioral intervention,health education and other aspects of research;AIDS medicine focused on generic engineering drugs,antiviral drugs,disease poison production and production technology,industry,research synthesis and formulation;the extraction of the active ingredients of traditional Chinese medicine,drug synthesis were included in the Chinese medicine.(3)A total of357AIDS-related projects were required from1999to2011,333of them were supported by the National Natural Science Fund projects,11by National Key Basic Research Program and13by the Ten,Eleven five year Technology Support Program. The number of the projects funded by the National Natural Science Foundation in the fields of AIDS increased yearly. The financial aids were strengthened and the funded projects focused on the basic disciplines such as virus, viral infection and host immunity, inflammation, infection and immunity, anti-infective drugs pharmacology and human virology.(4)The number of scientific and technical literature in the fields of AIDS increased from1983to2011by yearly. The Chinese Center for Disease Control(CDC) have got the most literatures published and have the most significant cooperation with the CDC in various regions.The cooperation between the scientific research institutions in China and the United Stateds up to the most,followed by the Australia, Switzerland, Japan and India. Cluster analysis showed that the scientific literature included the AIDS basic, clinical, preventive control, pharmacy and traditional Chinese medicine in the pharmacy. The HIV life cycle, gene structure, pathogenesis, HIV vaccine were included in AIDS basic research areas; clinical study focused on AIDS co-infection of sexually transmitted diseases, tuberculosis, cancer, and opportunistic infections and other diseases and their clinical features, diagnosis, treatment, adverse reactions, nursing, clinical analysis; prevention and public health research concentrated in the AIDS intervention, evaluation, monitoring, investigation, monitoring and evaluation, testing and consulting, laboratory management, reporting, etc.; the AIDS pharmaceutical research was reflected in the anti-viral drug design, drug discovery, drug selection, drug abuse, drug resistance; Chinese herbal formula, Pharmacology, long-term intervention of traditional Chinese medicine, and Chinese medicine treatment were included in the Chinese medicine pharmaceutical research.3.Based on the results of the keywords co-occurrence of the bibliometric analysis, we have done the resources planning in the fields of AIDS and constructed the first directory included basic research, clinical research, prevention and public health research, pharmaceutical research and traditional Chinese medicine and Chinese pharmaceutical research; the second directory contained38items such as the life cycle of the virus, gene structure, pathogenesis, HIV vaccine, HIVco-infection of sexually transmitted diseases, tuberculosis, cancer, and opportunistic infections and other diseases and their clinical features, diagnosis, treatment, adverse reactions, nursing, clinical analysis, AIDS intervention,evaluation, monitoring and evaluation, testing and counseling, laboratory management, reporting, antiviral drug design, drug development, drug selection, drug abuse, drug resistance, Chinese herbal formula, pharmacology, Chinese long-term interventions,efficacy of Chinese medicine and Chinese medicine treatment and the third directory which included147items such as viral gene results and main function, HIV intervention strategies, antigen-antibody detection of HIV-1membrane fusion inhibitors and herbal treatment.Conclusions:1.The business datas of the fields of AIDS were concentrated in the hands of Chinese Center for Disease Control and Prevention of STD and AIDS.2.The bibliometric analysis of the scientific and technological achievements,fund and literature data shows that the amount of information is large and so are the holders of information. Research focused on basic research, clinical research, prevention and public health research, pharmaceutical research and traditional Chinese medicine and Chinese pharmaceutical research.3.AIDS subject database framework design oriented the business activities of the AIDS field and used the information resource planning methods, literature review and expert meetings law to build three directory database framework with five the first directory,38the second directory and147the third directory. But we still need to invite experts in the basic research, clinical research, prevention and public health research, pharmaceutical research and traditional Chinese medicine and Chinese pharmaceutical research to further assess the framework and contact with the resource owners to fill the framework and modified it in the aims to make the best use of the AIDS-related resources.