Research On The Relevance Between Serum RBP4Level And Coronary Heart Disease Combined With Renal Injury

Background:Retinol binding protein4(RBP4) is a new adipocyte factorparticipating in the insulin resistance, a factor that is authenticated byYang from Medical School of Harvard University with gene chiptechnology. It advances the research on obesity, IR, adipocytokine,inflammation and metabolic syndrome and is introduced to the field ofnephropathy, which is of great significance to the early diagnosis ofnephropathy. RBP4is also intimately related with the occurrence ofcoronary heart disease. As renal failure is regarded as one of theimportant death factors for coronary heart disease, it is, therefore, ofessential significance to provide early sensitive testing index for coronaryheart disease combined with renal failure.Objective：To investigate the relationship between retinol binding protein4andcoronary heart disease combined with renal failure and providetheoretical basis for the prediction of coronary heart disease combinedwith renal failure.Methods：100patients who went to our hospital from January2014to January2015and were diagnosed with coronary heart disease are collected; allthese patients were subject to selective coronary angiographyexamination for definite diagnosis. Through normal examination,50were proven healthy are collected.The experiment was divided into3groups:50patients with coronary heart disease with renal damage were set to Agroup, the group of patients underwent urine routine examination, urinealbumin was positive.50patients with single coronary heart disease wereset to B group, and50patients with normal physical examination were Cgroup. The expression of RBP4in the3groups was detected by immuneassay, and the expression of serum factor urea nitrogen and creatinine in3experimental groups was detected. Statistical treatment encompasseschi-square test, CMH test and Logistic regression analysis of influencingfactors.Results:Compared with normal control group (Group C), expression ofretinol binding protein4(RBP4) in the coronary heart diseasecomplicated with renal injury group (group A) was significantly increased(P <0.01) and the expression in the coronary heart disease (group B) wasincreased (P <0.05), and serum urea nitrogen and creatinine el serummarkers among group A,B and group C was statistically significant (P <0.05), and expression of group A and group B showed no statisticalsignificance (P>0.05).Conclusion：The increase of RBP4in blood was significantly correlated with theextent of coronary lesions and renal damage, and the increase of RBP4was a risk factor for the renal damage in coronary artery disease. Due torenal injury was involved in many signal transduction pathways, RBP4expression is elevated in renal damage,so inhibition of RBP4expressionblocking the pathological process of renal injury, which have greatsignificance for mining new drugs that inhibit RBP4expression..