Effect Of Smoking On The Levels Of Norepinephrine In Peripheral Blood Of Patients With Coronary Heart Disease

Objective:To investigate the change of smoking history of coronary heart disease patients with sympathetic, smoking on the sympathetic nervous system in patients with coronary heart disease (CHD) changes. The experiment through to coronary heart disease patients (with or without smoking history) for admission test routine project check (blood and urine routine, blood glucose, blood electrolytes, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density fat cholesterol, uric acid, myocardial enzymes, plasma to norepinephrine) index was evaluated.Methods:We collected during February September2012to2015,referred to the circulation department of China Japan Union Hospital of Jilin University in coronary heart disease patients with210people, age:38-72years. Among them,138male, female72people. Respectively according to smoking index (heaviness of smoking index, HSI) and daily smoking number (number of400cigarettes per day, cpd) were divided into two groups. Smoking index according to the general international standard, namely:HIS=*CPD years of smoking. His0patients with coronary heart disease (CHD) is a non-smoking control group; his greater than0patients as group A, which will group A in his less than100mild smoking dependence group (group A1), his between100-300for moderate smoking dependence group (group A2),his more than300heavy smoking dependence group (A3group);Results:(1):non smoking control group were50people, mild smoking dependence group(group:A1)18people, moderate smoking dependence group (group A2)32people, heavy smoking dependence group (A3group)30.(2) peripheral blood test results:A1, A2, A3group, the serum TC, LDL-C, HDL-C and TG value and non smoking compared to the control group, the difference was not statistically significant (P>0.05); see Table1. Detection of peripheral blood of NE and non smoking group to26.66+17.6ng/L, group A1was23.9ng/L and399.8+and A2group to4.283+46.7ng/L, A3group for4.438+6.32ng/L. The results showed that Al, A2, A3group NE were higher than the non-moking group. Statistical analysis showed that:A1, A2and NE value in A3group compared with the control group, there were significant differences (P＜0.05); see table2. (3) smoking group a group in NE contrast detection, A3group ne values compared with groups of A1and A2ne values, NE although there is an upward trend, but no significant difference (P>0.05); see Table3(4) control group and smoking group of patients with arrhythmia occurrence probability comparison, smoking group patients the incidence of arrhythmia was significantly higher than that of the control group; see Table4Conclusion:1. smoking patients with coronary heart disease in the plasmanorepinephrine levels were significantly higher than those without smoking history in patients with coronary heart disease;2.high smoking index in patients with coronary heart disease in the peripheral bloodlevels of norepinephrine are also on the rise;3.smoking may increase the incidence of arrhythmia in patients with coronary heart disease.